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Structural and technological characterization of pectin extracted with sodium citrate and nitric acid from sunflower heads

Published: Jun 13, 2018

Author(s): Nerea Muñoz‐Almagro, Fabián Rico‐Rodriguez, Peter J. Wilde, Antonia Montilla, Mar Villamiel

Journal: ELECTROPHORESIS

Abstract An optimization of temperature, time, and extracting agent concentration of pectin extraction from sunflower heads using sodium citrate and nitric acid (SP‐SC and SP‐NA) was carried out. At optimal conditions, the yield of extraction with nitric acid (SPO‐NA) was twofold greater than the corresponding with sodium citrate (SPO‐SC) (14.3 versus 7.7%, respectively). Regarding pectin structure, the galacturonic acid (GalA)...

Read More thumbnail image: Structural and technological characterization of pectin extracted with sodium citrate and nitric acid from sunflower heads

Simultaneous quantification of fentanyl, sufentanil, cefazolin, doxapram and keto‐doxapram in plasma using liquid chromatography–tandem mass spectrometry

Published: Jun 12, 2018

Author(s): Robert B. Flint, Soma Bahmany, Bart C. H. Nagel, Birgit C. P. Koch

Journal: Biomedical Chromatography

Abstract A simple and specific UPLC–MS/MS method was developed and validated for simultaneous quantification of fentanyl, sufentanil, cefazolin, doxapram and its active metabolite keto‐doxapram. The internal standard was fentanyl‐d5 for all analytes. Chromatographic separation was achieved with a reversed‐phase Acquity UPLC HSS T3 column with a run‐time of only 5.0 min per injected sample. Gradient elution was performed with a...

Read More thumbnail image: Simultaneous quantification of fentanyl sufentanil cefazolin doxapram and ketodoxapram in plasma using liquid chromatographytandem mass spectrometry

Rapid preparation of molecularly imprinted polymers by custom‐made microwave heating for analysis of atrazine in water

Published: Jun 12, 2018

Author(s): Pamornrat Kueseng, Mudtorlep Nisoa, Chonlatid Sontimuang

Journal: Journal of Separation Science

Abstract The rapid preparation of an atrazine‐imprinted polymer in a cost‐effective custom‐made microwave reactor was demonstrated. The polymerization reaction was accelerated by microwave heating, and the preparation time was greatly shortened (to 1 h). The resulting polymer was successfully applied as solid‐phase extraction adsorbent for the selective extraction and preconcentration of atrazine in environmental water samples. The...

Read More thumbnail image: Rapid preparation of molecularly imprinted polymers by custommade microwave heating for analysis of atrazine in water

An integrated multipath liquid chromatography–mass spectrometry system for the simultaneous preparation, separation, and detection of proteins and small molecules

Published: Jun 12, 2018

Author(s): Dananjaya Kalu Appulage, Evelyn H. Wang, Benjamin J. Figard, Kevin A. Schug

Journal: Journal of Separation Science

Abstract A multipath liquid chromatography with mass spectrometry instrument was constructed with the help of restricted access media to online segregate small and large molecules. This liquid chromatography system was custom built with five pumps and three two‐position six‐port valves to control the flow in a multipath system for the simultaneous analysis of small molecules and proteins. On separate chromatographic channels, small...

Read More thumbnail image: An integrated multipath liquid chromatographymass spectrometry system for the simultaneous preparation separation and detection of proteins and small molecules

Determining the effects of adulterants on drug detection via enzyme‐linked immunosorbent assay and adulterant tests strips

Published: Jun 11, 2018

Author(s): Bianca Olivieri, Mark Marić, Candice Bridge

Journal: Drug Testing and Analysis

Abstract The use of immunoassays for drug screening has increased due to their sensitivity towards target analytes, specifically the enzyme‐linked immunosorbent assay (ELISA) technique. Adulterant test strips are commonly used in conjunction with immunoassay tests to ensure the integrity of the specimen has not been altered prior to drug screening. This research focuses on determining which adulterants can produce a false negative...

Read More thumbnail image: Determining the effects of adulterants on drug detection via enzymelinked immunosorbent assay and adulterant tests strips

Simultaneous quantitation of rosuvastatin and ezetimibe in human plasma by LC–MS/MS: Pharmacokinetic study of fixed‐dose formulation and separate tablets

Published: Jun 11, 2018

Author(s): Abhaysingh Bhadoriya, Mallika Sanyal, Priyanka A. Shah, Pranav S. Shrivastav

Journal: Biomedical Chromatography

Abstract A simple, high‐throughput and highly sensitive liquid chromatography coupled with tandem mass spectrometry (LC–MS/MS) method has been developed for the simultaneous estimation of rosuvastatin and free ezetimibe. Liquid–liquid extraction was carried out using methyl‐tert butyl ether after prior acidification from 300 μL human plasma. The recovery for both the analytes and their deuterated internal standards (ISs) ranged from...

Read More thumbnail image: Simultaneous quantitation of rosuvastatin and ezetimibe in human plasma by LCMSMS Pharmacokinetic study of fixeddose formulation and separate tablets

Development of an HPLC‐DAD method for the determination of five alkaloids in Stephania yunnanensis Lo and in rat plasma after oral dose of Stephania yunnanensis Lo extracts

Published: Jun 11, 2018

Author(s): Aiyi Xin, Yaming Zhang, Yanxia Zhang, Duolong Di, Junxi Liu

Journal: Biomedical Chromatography

Abstract For the rational utilization and the quantitative quality control of the Stephania yunnanensis Lo, an HPLC‐DAD method was developed for the quantitative and simultaneous determination of five alkaloids in rat plasma (stepharine, sinomenine, palmatine, isocorydine and tetrahydropalmatine), which were the main active chemical constituents of this plant and belong to four kinds of isoquinoline‐type alkaloids (protoberberine, morphine,...

Read More thumbnail image: Development of an HPLCDAD method for the determination of five alkaloids in Stephania yunnanensis Lo and in rat plasma after oral dose of Stephania yunnanensis Lo extracts

Chiral separation of isoxanthohumol and 8‐prenylnaringenin in beer, hop pellets and hops by HPLC with chiral columns

Published: Jun 11, 2018

Author(s): Hyuga Moriya, Sohei Tanaka, Yukari Iida, Satomi Kitagawa, Sen‐ichi Aizawa, Atsushi Taga, Hiroyuki Terashima, Atsushi Yamamoto, Shuji Kodama

Journal: Biomedical Chromatography

Abstract Xanthohumol, isoxanthohumol, and 8‐prenylnaringenin in beer, hop and hop pellet samples were analyzed by HPLC using an InertSustain phenyl column and the mobile phase containing 40% methanol and 12% 2‐propanol. Fractions of isoxanthohumol and 8‐prenylnaringenin obtained by the above HPLC were separately collected. Isoxanthohumol and 8‐prenylnaringenin were enantioseparated by HPLC using a Chiralcel OD‐H column with a mobile...

Read More thumbnail image: Chiral separation of isoxanthohumol and 8prenylnaringenin in beer hop pellets and hops by HPLC with chiral columns

Proteomic characterization of a selenium‐metabolizing probiotic Lactobacillus reuteri Lb2 BM for nutraceutical applications

Published: Jun 11, 2018

Author(s): Cristina Lamberti, Erika Mangiapane, Alessandro Pessione, Roberto Mazzoli, Carlo Giunta, Enrica Pessione

Journal: PROTEOMICS

Read More thumbnail image: Proteomic characterization of a seleniummetabolizing probiotic Lactobacillus reuteri Lb2 BM for nutraceutical applications

Antibody Profiling by Proteome Microarray with Multiplex Isotype Detection Reveals Overlap between Human and Aotus nancymaae Controlled Malaria Infections

Published: Jun 11, 2018

Author(s): Omid Taghavian, Aarti Jain, Chester J. Joyner, Sunny Ketchum, Rie Nakajima, Algis Jasinskas, Li Liang, Rich Fong, Christopher King, Bryan Greenhouse, Maxwell Murphy, Jason Bailey, Mary R. Galinski, John W. Barnwell, Christopher V. Plowe, D. Huw Davies, Philip L. Felgner

Journal: PROTEOMICS

Read More thumbnail image: Antibody Profiling by Proteome Microarray with Multiplex Isotype Detection Reveals Overlap between Human and Aotus nancymaae Controlled Malaria Infections

Inverse surface‐enhanced spatially offset Raman spectroscopy (SESORS) through a monkey skull

Published: Jun 11, 2018

Author(s): Ren A. Odion, Pietro Strobbia, Bridget M. Crawford, Tuan Vo‐Dinh

Journal: Journal of Raman Spectroscopy

Abstract The use of nanoparticles in nanomedicine has received increasing interest. However, in vivo detection of nanoparticles using optical techniques is still a formidable challenge. Detecting surface‐enhanced Raman scattering (SERS)‐labeled nanoparticles through thick tissue is crucial due to its large number of potential applications in the field of disease diagnostics and monitoring. As gold nanoparticles are becoming an...

Read More thumbnail image: Inverse surfaceenhanced spatially offset Raman spectroscopy SESORS through a monkey skull

DNA adducts: Formation, biological effects, and new biospecimens for mass spectrometric measurements in humans

Published: Jun 11, 2018

Author(s): Byeong Hwa Yun, Jingshu Guo, Medjda Bellamri, Robert J. Turesky

Journal: Mass Spectrometry Reviews

Hazardous chemicals in the environment and diet or their electrophilic metabolites can form adducts with genomic DNA, which can lead to mutations and the initiation of cancer. In addition, reactive intermediates can be generated in the body through oxidative stress and damage the genome. The identification and measurement of DNA adducts are required for understanding exposure and the causal role of a genotoxic...

Read More thumbnail image: DNA adducts Formation biological effects and new biospecimens for mass spectrometric measurements in humans

Proteomics biomarkers for solid tumors: Current status and future prospects

Published: Jun 11, 2018

Author(s): Iwona Belczacka, Agnieszka Latosinska, Jochen Metzger, David Marx, Antonia Vlahou, Harald Mischak, Maria Frantzi

Journal: Mass Spectrometry Reviews

Cancer is a heterogeneous multifactorial disease, which continues to be one of the main causes of death worldwide. Despite the extensive efforts for establishing accurate diagnostic assays and efficient therapeutic schemes, disease prevalence is on the rise, in part, however, also due to improved early detection. For years, studies were focused on genomics and transcriptomics, aiming at the discovery of new tests...

Read More thumbnail image: Proteomics biomarkers for solid tumors Current status and future prospects

Ultra high performance liquid chromatography with tandem mass spectrometry method for determining dinotefuran and its main metabolites in samples of plants, animal‐derived foods, soil, and water

Published: Jun 10, 2018

Author(s): Ying Zhang, Xiaohu Wu, Tingting Duan, Jun Xu, Fengshou Dong, Xingang Liu, Xiaogang Li, Pengqiang Du, Yongquan Zheng

Journal: Journal of Separation Science

Abstract An ultra high‐performance liquid chromatography with tandem triple quadrupole mass spectrometry residue method was developed and validated for the quantification and identification of dinotefuran and its main metabolites 1‐methyl‐3‐(tetrahydro‐3‐furylmethyl) urea and 1‐methyl‐3‐(tetrahydro‐3‐furylmethyl) guanidine in fruit (watermelon), vegetable (cucumber), cereal (rice), animal‐derived foods (milk, egg, and pork), soil,...

Read More thumbnail image: Ultra high performance liquid chromatography with tandem mass spectrometry method for determining dinotefuran and its main metabolites in samples of plants animalderived foods soil and water

Application of liquid–liquid microextraction for the effective separation and simultaneous determination of 11 pharmaceuticals in wastewater samples using high‐performance liquid chromatography with tandem mass spectrometry

Published: Jun 10, 2018

Author(s): Alina Diuzheva, József Balogh, József Jekő, Zoltán Cziáky

Journal: Journal of Separation Science

Abstract A dispersive liquid–liquid microextraction method for the simultaneous determination of 11 pharmaceuticals has been developed. The method is based on a microextraction procedure applied to wastewater samples from different regions of Hungary followed by high‐performance liquid chromatography with mass spectrometry. The effect of the nature of the extractant, dispersive solvent, different additives, and extraction time were...

Read More thumbnail image: Application of liquidliquid microextraction for the effective separation and simultaneous determination of 11 pharmaceuticals in wastewater samples using highperformance liquid chromatography with tandem mass spectrometry

Cost‐efficient magnetic nanoporous carbon derived from citrus peel for the selective adsorption of seven insecticides

Published: Jun 10, 2018

Author(s): Yuantao Zhou, Shurui Cao, Cunxian Xi, Jiuyan Chen, Lei Zhang, Xianliang Li, Guomin Wang, Zhiqiong Chen

Journal: Journal of Separation Science

Abstract A magnetic solid‐phase extraction adsorbent that consisted of citrus peel‐derived nanoporous carbon and silica‐coated Fe3O4 microspheres (C/SiO2@Fe3O4) was successfully fabricated by co‐precipitation. As a modifier for magnetic microspheres, citrus peel‐derived nanoporous carbon was not only economical and renewable for its raw material, but exerted enormous nanosized pore structure, which could directly influence the type of adsorbed...

Read More thumbnail image: Costefficientmagnetic nanoporous carbon derived from citrus peel for the selective adsorption of seven insecticides

Protonation of polyaniline‐coated silica stationary phase affects the retention behavior of neutral hydrophobic solutes in reversed‐phase capillary liquid chromatography

Published: Jun 10, 2018

Author(s): Lukáš Taraba, Tomáš Křížek, Petr Kozlík, Ondřej Hodek, Pavel Coufal

Journal: Journal of Separation Science

Abstract Because of its high conductivity when acid doped, polyaniline is known as a synthetic metal and is used in a wide range of applications, such as supercapacitors, biosensors, electrochromic devices, or solar and fuel cells. Emeraldine is the partly oxidized, stable form of polyaniline, consisting of alternating diaminobenzenoid and iminoquinoid segments. When acidified, the nitrogen atoms of emeraldine become protonated. Due...

Read More thumbnail image: Protonation of polyanilinecoated silica stationary phase affects the retention behavior of neutral hydrophobic solutes in reversedphase capillary liquid chromatography

Proteolysis to Identify Protease Substrates: Cleave to Decipher

Published: Jun 10, 2018

Author(s): Sonali R. Bhagwat, Krishnan Hajela, Amit Kumar

Journal: PROTEOMICS

Abstract Proteolysis is an irreversible post‐translational modification process, characterized by highly precise yet stable cleavage of proteins. Downstream events in signaling processes are reliant on proteolysis triggered by the protease activity. Studies indicate that abnormal proteolytic activity may lead to the manifestation of diseased conditions. Therefore, characterization of proteases may provide clues to understand their...

Read More thumbnail image: Proteolysis to Identify Protease Substrates Cleave to Decipher

Mining for Microbial Gems: Integrating Proteomics in the Postgenomic Natural Product Discovery Pipeline

Published: Jun 10, 2018

Author(s): Chao Du, Gilles P. Wezel

Journal: PROTEOMICS

Abstract Natural products (NPs) are a major source of compounds for medical, agricultural, and biotechnological industries. Many of these compounds are of microbial origin, and, in particular, from Actinobacteria or filamentous fungi. To successfully identify novel compounds that correlate to a bioactivity of interest, or discover new enzymes with desired functions, systematic multiomics approaches have been developed over the...

Read More thumbnail image: Mining for Microbial Gems Integrating Proteomics in the Postgenomic Natural Product Discovery Pipeline

Analysis of PNGase F‐Resistant N‐Glycopeptides Using SugarQb for Proteome Discoverer 2.1 Reveals Cryptic Substrate Specificities

Published: Jun 10, 2018

Author(s): Johannes Stadlmann, David M. Hoi, Jasmin Taubenschmid, Karl Mechtler, Josef M. Penninger

Journal: PROTEOMICS

Abstract SugarQb ( www.imba.oeaw.ac.at/sugarqb) is a freely available collection of computational tools for the automated identification of intact glycopeptides from high‐resolution HCD MS/MS datasets in the Proteome Discoverer environment. We report the migration of SugarQb to the latest and free version of Proteome Discoverer 2.1, and apply it to the analysis of PNGase F‐resistant N‐glycopeptides from mouse embryonic stem cells. ...

Read More thumbnail image: Analysis of PNGase FResistant NGlycopeptides Using SugarQb for Proteome Discoverer 2_1 Reveals Cryptic Substrate Specificities
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