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Studies on excretion kinetics of ten constituents in rat urine after oral administration of Shensong Yangxin Capsule by UPLC‐MS/MS
Published: Oct 9, 2013
Author(s): Minyan Liu, Song Li, Shaohua Zhao, Hongtao Wang, Hairong Wang, Pengfei Tu
Journal: Biomedical Chromatography
ABSTRACT A rapid and sensitive ultra‐high performance liquid chromatography–mass spectrometry (UPLC‐MS/MS) method was developed and validated for the quantification of 10 major active constituents in rat urine after oral administration of Shensong Yangxin Capsule (SSYX) using diazepam as an internal standard (IS). The urine samples were pretreated and extracted by solid‐phase extraction prior to UPLC. Chromatographic separation was...
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Simultaneous determination of four components in Baige capsule by HPLC: application to pharmacokinetics and tissue distribution of normal and middle cerebral artery occlusion rats
Published: Oct 9, 2013
Author(s): Yuanji Wang, Nan Wang, Lei Wu, Wen Lu, Yanmin Zhang
Journal: Biomedical Chromatography
ABSTRACT A sensitive and specific high‐performance liquid chromatography (HPLC) method was developed and applied to the pharmacokinetics for simultaneous identification and quantification of four components – puerarin, daidzein, imperatorin and isoimperatorin – in the plasma and tissues of normal and middle cerebral artery occlusion rats after oral administration of Baige capsule. Ferulic was used as the internal standard. The...
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A quantitative analysis of the polyamine in lung cancer patient fingernails by LC‐ESI‐MS/MS
Published: Oct 9, 2013
Author(s): Jun Zhe Min, Akihito Matsumoto, Gao Li, Ying‐Zi Jiang, Hai‐fu Yu, Kenichiro Todoroki, Koichi Inoue, Toshimasa Toyo'oka
Journal: Biomedical Chromatography
ABSTRACT A quantitative analysis of polyamines in lung cancer patient fingernails by the combination of 4‐(N,N‐dimethylaminosulfonyl)‐7‐fluoro‐2,1,3‐benzoxadiazole derivatives and liquid chromatography–electrospray ionization tandem mass spectrometry is described. The reaction of the reagent with eight kinds of polyamines, that is, N1‐acetylputrescine (N1‐actPUT), N8‐acetylspermidine, N1‐acetylspermine, 1,3‐diaminopropane, putrescine (PUT), cadaverine,...
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HPLC‐Q‐TOF‐MS/MS for analysis of major chemical constituents of Yinchen–Zhizi herb pair extract
Published: Oct 9, 2013
Author(s): Zhiwen Fu, Yun Ling, Zhixiong Li, Mingcang Chen, Zhaolin Sun, Chenggang Huang
Journal: Biomedical Chromatography
ABSTRACT The Yinchen–Zhizi herb pair (YZHP) consists of Herba Artemisiae Scopariae (Yinchen in Chinese) and Fructus Gardeniae (Zhizi in Chinese), and is mainly used to treat icteric hepatitis, itching skin and eczema. However, the bioactive constituents responsible for the pharmacological effects of YZHP are still unclear to date. In this work, a rapid and sensitive method was established to comprehensively study the constituents in...
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Solvent bar microextraction combined with high‐performance liquid chromatography for preconcentration and determination of pramipexole in biological samples
Published: Oct 9, 2013
Author(s): Ensieh Ghasemi, Salim Kheradmand, Orkideh Ghorban Dadrass
Journal: Biomedical Chromatography
ABSTRACT A simple, rapid and sensitive analytical method for preconcentration and determination of pramipexole in different biological samples has been developed using solvent bar microextraction (SBME) combined with HPLC‐UV. The target drugs were extracted from 10 mL of basic aqueous sample solution into an organic extracting solvent located inside the pores of a polypropylene hollow fiber, then back‐extracted into an acidified...
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Determination of rhynchophylline and hirsutine in rat plasma by UPLC‐MS/MS after oral administration of Uncaria rhynchophylla extract
Published: Oct 9, 2013
Author(s): Yu‐Tse Wu, Lie‐Chwen Lin, Tung‐Hu Tsai
Journal: Biomedical Chromatography
ABSTRACT An ultra‐performance liquid chromatography with tandem mass spectrometry (UPLC–MS/MS) method was developed and validated to concurrently determine rhynchophylline and hirsutine in rat plasma. The sample preparation of rat plasma was achieved by alkalization and liquid–liquid extraction. The mass transition of precursor ion → product ion pairs were monitored at m/z 385.2 → 160.0 for rhynchophylline, m/z 369.3 → 144.0 for hirsutine and...
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Using induced electroosmotic micromixer to enhance the reproducibility of chemiluminescence intensity
Published: Oct 9, 2013
Author(s): Hsiao‐Ping Chen, Chun‐Yi Yeh, Pei‐Chin Hung, Shau‐Chun Wang
Journal: ELECTROPHORESIS
In this study, induced electroosmotic vortex flows were generated using an AC electric field by one pair of external electrodes to rapidly mix luminescence reagents in a 30 μL micromixer and enhance the reproducibility of chemiluminescence (CL) assays. A solution containing the catalyst reagent ferricyanide ions (4 μL) was pipetted into a reservoir containing luminol to produce CL in the presence of hydrogen peroxide. When the added...
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Characterization of a hybrid dielectrophoresis and immunocapture microfluidic system for cancer cell capture
Published: Oct 9, 2013
Author(s): Chao Huang, Steven M. Santana, He Liu, Neil H. Bander, Benjamin G. Hawkins, Brian J. Kirby
Journal: ELECTROPHORESIS
The capture of circulating tumor cells (CTCs) from cancer patient blood enables early clinical assessment as well as genetic and pharmacological evaluation of cancer and metastasis. Although there have been many microfluidic immunocapture and electrokinetic techniques developed for isolating rare cancer cells, these techniques are often limited by a capture performance tradeoff between high efficiency and high purity. We present the...
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Dipyridyl‐immobilized ionic liquid type hybrid silica monolith for hydrophilic interaction electrochromatography
Published: Oct 9, 2013
Author(s): Xiao Wang, Na Zheng, Yifang Huang, Jiabin Wang, Xucong Lin, Zenghong Xie
Journal: ELECTROPHORESIS
A pyridinium‐based immobilized ionic liquid type multifunctional hybrid silica monolith was prepared by the in situ polymerization of 3‐chloropropyl‐silica matrix and 4,4′‐dipyridyl for hydrophilic interaction CEC. The obtained hybrid monolith possessed of high stable skeletal microstructures with obviously hydrophilic retention mechanism under ACN content >50% in the mobile phase. Strong and stable anodic EOF could be observed under a...
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Modeling of misalignment effects in microfluidic interconnects for modular bio‐analytical chip applications
Published: Oct 9, 2013
Author(s): Sudheer D. Rani, Taehyun Park, Byoung Hee You, Steve A. Soper, Michael C. Murphy, Dimitris E. Nikitopoulos
Journal: ELECTROPHORESIS
Minimizing misalignments during the interconnection of microfluidic modules is extremely critical to develop a fully integrated microfluidic device. Misalignments arising during chip‐to‐chip or world‐to‐chip interconnections can be greatly detrimental to efficient functioning of microfluidic devices. To address this problem, we have performed numerical simulations to investigate the effect of misalignments arising in three types of...
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Enhanced penetration of fluoride particles into bovine enamel by combining dielectrophoresis with AC electroosmosis
Published: Oct 9, 2013
Author(s): Chris S. Ivanoff, Nathan S. Swami, Timothy L. Hottel, Franklin Garcia‐Godoy
Journal: ELECTROPHORESIS
Fluoride deposition into the pores of enamel is necessary at high concentrations to reduce enamel demineralization and with a high degree of penetration to account for loss by ingestion. Current diffusion and electrochemical methods are inadequate for effectively transporting fluoride greater than 20 μm into enamel. The study explores the coupling of dielectrophoresis (DEP) and AC electroosmosis (ACEO) to selectively concentrate fluoride...
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Optimization of electrospun TiO 2 nanofibers photoanode film for dye‐sensitized solar cells through interfacial pre‐treatment, controllable calcination, and surface post‐treatment
Published: Oct 9, 2013
Author(s): Pingfan Du, Lixin Song, Jie Xiong, Can Cui
Journal: Surface and Interface Analysis
Dye‐sensitized solar cells (DSSCs) are generally viewed as next generation photovoltaic devices. Electrospun TiO2 nanofibers (NFs) film can be used to construct photoanode for DSSCs. A systematic strategy to optimize such a novel photoanode material of DSSCs was elaborated in this paper. A main drawback of NFs photoanode is the poor adhesion of ceramic NFs film to its conductive glass substrate. This problem can be well solved by sandwiching a...
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High‐resolution MRI of uveal melanoma using a microcoil phased array at 7 T
Published: Oct 7, 2013
Author(s): J. W. M. Beenakker, G. A. Rijn, G. P. M. Luyten, A. G. Webb
Journal: NMR in Biomedicine
High‐field MRI is a promising technique for the characterisation of ocular tumours, both in vivo and after enucleation. For in vivo imaging at 7 T, a dedicated three‐element microcoil array was constructed as a high‐sensitivity receive‐only device. Using a dedicated blink/fixation protocol, high‐resolution in vivo images could be acquired within 3 min in volunteers and patients with no requirement for post‐acquisition image registration. Quantitative...
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Cerebral blood flow response to acute hypoxic hypoxia
Published: Oct 7, 2013
Author(s): Ashley D. Harris, Kevin Murphy, Claris M. Diaz, Neeraj Saxena, Judith E. Hall, Thomas T. Liu, Richard G. Wise
Journal: NMR in Biomedicine
Hypoxic hypoxia (inspiratory hypoxia) stimulates an increase in cerebral blood flow (CBF) maintaining oxygen delivery to the brain. However, this response, particularly at the tissue level, is not well characterised. This study quantifies the CBF response to acute hypoxic hypoxia in healthy subjects. A 20‐min hypoxic (mean PETo2 = 52 mmHg) challenge was induced and controlled by dynamic end‐tidal forcing whilst CBF was measured using pulsed arterial ...
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Preparation of 17β‐estradiol surface molecularly imprinted polymers and their application to the analysis of biological samples
Published: Oct 7, 2013
Author(s): Jing Zhang, Lingling Wang, Yanting Han
Journal: Journal of Separation Science
17β‐Estradiol (E2) surface molecularly imprinted polymers have been prepared using functionalized monodispersed poly(glycidyl methacrylate‐co‐ethylene dimethacrylate) beads as a support. The resulting polymers were found to be uniform in size (5 μm), and the surfaces of the microspheres possessed large pore‐like structures. A chromatographic experiment demonstrated that the resulting microspheres exhibited high levels of recognition and...
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Ionic‐liquid‐based dispersive liquid–liquid microextraction for high‐throughput multiple food contaminant screening
Published: Oct 7, 2013
Author(s): Yee‐Man Ho, Yeuk‐Ki Tsoi, Kelvin Sze‐Yin Leung
Journal: Journal of Separation Science
This paper describes an innovation of dispersive liquid–liquid microextraction enabling multiple‐component analysis of eight high‐priority food contaminants in two chemically distinctive families: Sudan dyes and phthalate plasticizers. To provide convenient sample handling for solid and solid‐containing matrices, a modified dispersive liquid–liquid microextraction procedure used an extractant precoated frit to perform simultaneous...
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Comparison of interpolation polynomials with divided differences, interpolation polynomials with finite differences, and quadratic functions obtained by the least squares method in modeling of chromatographic responses
Published: Oct 7, 2013
Author(s): Tijana Rakić, Zorica Stanimirović, Aleksandar Đenić, Miroslav Marić, Biljana Jančić‐Stojanović, Mirjana Medenica
Journal: Journal of Chemometrics
A novel approach to mathematical modeling of chromatographic responses based on interpolation polynomials with divided differences and with finite differences is discussed. These interpolational techniques as well as traditionally applied second‐order polynomial models obtained by least squares are compared. Interpolation techniques can be useful in situations where commonly used linear or quadratic models are not applicable: when the...
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The effectiveness of borneol on pharmacokinetics changes of four ginsenosides in Shexiang Baoxin Pill in vivo
Published: Oct 7, 2013
Author(s): Peng Jiang, Peng Fu, Li Xiang, Shuping Wang, Xiaojun Liu, Ling Yang, Jianfei Tao, Zhongliang Chen, Changsen Zhan, Ximing Huang, Runhui Liu, Weidong Zhang
Journal: Biomedical Chromatography
ABSTRACT Shexiang Baoxin Pill (SBP) is a traditional Chinese medicine, widely used for cardiovascular diseases in the clinic. Ginsenosides are important effective components in SBP, but their pharmacokinetic characteristics are still not known. In this paper, we studied the pharmacokinetics of ginsenoside Rb1, Rc, Re and Rg1 in SBP and investigated the effect of borneol on the pharmacokinetic characteristic of ginsenosides based on...
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Screening of testosterone esters in human plasma
Published: Oct 7, 2013
Author(s): G. Forsdahl, H.K. Vatne, T. Geisendorfer, G. Gmeiner
Journal: Drug Testing and Analysis
The detection of an intact ester of testosterone in plasma is leading towards unequivocal proof of the administration of exogenous testosterone. In the current study, a sensitive screening method for the detection of nine testosterone esters in human plasma was developed. By preparing oxime derivatives of intact testosterone esters, the sensitivity of the assay was increased. Furthermore, the method included liquid‐liquid extraction (LLE)...
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Systematic investigation of the incorporation mechanisms of zolpidem in fingernails
Published: Oct 7, 2013
Author(s): Milena M. Madry, Andrea E. Steuer, Tina M. Binz, Markus R. Baumgartner, Thomas Kraemer
Journal: Drug Testing and Analysis
Nails are attracting increasing interest in forensic toxicology as an alternative to hair. The goal of this study was to systematically investigate the incorporation of drugs in fingernails after single drug dose, exemplified for zolpidem. Fingernail samples from ring fingers were collected one week before, and then 24 h and weekly after intake for a period of three to five months. Hair samples were taken six weeks after intake. Nail...
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