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In vivo determination of carotenoid resonance excitation profiles of Chlorella vulgaris , Haematococcus pluvialis , and Porphyridium purpureum

Published: Dec 6, 2017

Author(s): Matthias Koch, Ann‐Kathrin Kniggendorf, Merve Meinhardt‐Wollweber, Bernhard Roth

Journal: Journal of Raman Spectroscopy

Abstract Under stress, certain species of algae produce pigments such as astaxanthin, β‐carotene, or phycoerythrin for protection against photosynthethic stress. These pigments are of high commercial demand, for example, as food additives. Measuring and maintaining stress conditions precisely are necessary for efficient pigment synthesis in algae cultures. We present resonance excitation maps of three common species of algae,...

Read More thumbnail image: In vivo determination of carotenoid resonance excitation profiles of Chlorella vulgaris  Haematococcus pluvialis  and Porphyridium purpureum

Determination of tubuloside B by LC‐MS/MS and its application to a pharmacokinetic study in rats

Published: Dec 6, 2017

Author(s): Shenbao Yang, Ruiying Qu, Peilu Sun, Shan Xiong, Siyi Yan, Zhipeng Deng

Journal: Biomedical Chromatography

Abstract Tubuloside B, a novel neuroprotective phenylethanoid, is a major active constituent of Cistanche tubulosa and Cistanche deserticola. A specific and sensitive liquid chromatography tandem mass spectrometry (LC‐MS/MS) method has been developed and validated for the quantification of tubuloside B in rat plasma. Sample preparation was conducted through a protein‐precipitation extraction with methanol using tubuloside A as internal standard...

Read More thumbnail image: Determination of tubuloside B by LCMSMS and its application to a pharmacokinetic study in rats

How does soaking wood in various pH buffers impact ToF‐SIMS spectra?

Published: Dec 6, 2017

Author(s): Robyn E. Goacher, Courtney L. Michienzi

Journal: Surface and Interface Analysis

During the production of biofuels and/or bioproducts, wood and other lignocellulosic materials are frequently exposed to buffers during enzyme treatments. Buffer pH varies according to the activity profiles of the enzyme(s) used. Time‐of‐flight secondary ion mass spectrometry (ToF‐SIMS) is an increasingly valuable analytical tool for the surface analysis of lignocellulosic solids, allowing for characterization of the lignin and...

Read More thumbnail image: How does soaking wood in various pH buffers impact ToFSIMS spectra

Validation of SERS enhancement factor measurements

Published: Dec 5, 2017

Author(s): R. Pilot, R. Bozio

Journal: Journal of Raman Spectroscopy

Abstract The huge signal enhancement that motivates the rapid spreading of surface‐enhanced Raman scattering (SERS) in a wide range of applications is commonly quantified by measuring the enhancement factor (EF). Concerning this important parameter, in this paper, we tackle 2 points: (a) We validate the use of a Macro Raman configuration with line focus to measure the EFs, against the more common Micro Raman one. The validation is...

Read More thumbnail image: Validation of SERS enhancement factor measurements

MDA, MDMA, and other “mescaline‐like” substances in the US military's search for a truth drug (1940s to 1960s)

Published: Dec 5, 2017

Author(s): Torsten Passie, Udo Benzenhöfer

Journal: Drug Testing and Analysis

Abstract This article describes the context in which 3,4‐methylenedioxyamphetamine (MDA), 3,4‐methylenedioxymethamphetamine (MDMA) and other mescaline‐like compounds were explored as hallucinogens for military and intelligence purposes from the 1940s to the 1960s. Germans first tested mescaline as a “truth drug” in a military context. In the 1940s, the United States military started testing hallucinogenic substances as truth drugs...

Read More thumbnail image: MDA MDMA and other mescalinelike substances in the US militarys search for a truth drug 1940s to 1960s

Proteomics analysis of altered proteins in kidney of mice with aristolochic acid nephropathy using the fluorogenic derivatization–liquid chromatography–tandem mass spectrometry method

Published: Dec 5, 2017

Author(s): Chia‐En Lin, Wen‐Shin Chang, Jen‐Ai Lee, Ting‐Ya Chang, Yu‐Shen Huang, Yoshiro Hirasaki, Hung‐Shing Chen, Kazuhiro Imai, Shih‐Ming Chen

Journal: Biomedical Chromatography

Abstract Aristolochic acid (AA) causes interstitial renal fibrosis, called aristolochic acid nephropathy (AAN). There is no specific indicator for diagnosing AAN, so this study aimed to investigate the biomarkers for AAN using a proteomics method. The C3H/He female mice were given ad libitum AA–distilled water (0.5 mg/kg/day) and distilled water for 56 days in the AA and normal groups, respectively. The AA‐induced proteins in the...

Read More thumbnail image: Proteomics analysis of altered proteins in kidney of mice with aristolochic acid nephropathy using the fluorogenic derivatizationliquid chromatographytandem mass spectrometry method

Pharmacokinetics of pidotimod in broiler chickens by UHPLC–MS/MS after oral and intravenous administration

Published: Dec 5, 2017

Author(s): Ruili Zhang, Mei Qiu, Li Zhao, Liangliang Cui, Chunyuan Wang, Jiajia Zhu, Zhihui Hao

Journal: Biomedical Chromatography

Abstract Pidotimod is widely used in children as an immune promoter but it has not been fully evaluated in animals. The pharmacokinetics of pidotimod and its oral bioavailability have not been described in broiler chickens. We developed a simple and sensitive UHPLC–MS/MS assay for rapid determination of pidotimod levels in chicken blood. Recoveries were nearly 100% and the coefficients of accuracy and precision were minimal. Healthy...

Read More thumbnail image: Pharmacokinetics of pidotimod in broiler chickens by UHPLCMSMS after oral and intravenous administration

Impact of intratumoral heterogeneity of breast cancer tissue on quantitative metabolomics using high‐resolution magic angle spinning 1 H NMR spectroscopy

Published: Dec 5, 2017

Author(s): Mikheil Gogiashvili, Salome Horsch, Rosemarie Marchan, Kathrin Gianmoena, Cristina Cadenas, Berno Tanner, Sabrina Naumann, Diana Ersova, Frank Lippek, Jörg Rahnenführer, Jan T. Andersson, Roland Hergenröder, Jörg Lambert, Jan G. Hengstler, Karolina Edlund

Journal: NMR in Biomedicine

High‐resolution magic angle spinning (HR MAS) nuclear magnetic resonance (NMR) spectroscopy is increasingly being used to study metabolite levels in human breast cancer tissue, assessing, for instance, correlations with prognostic factors, survival outcome or therapeutic response. However, the impact of intratumoral heterogeneity on metabolite levels in breast tumor tissue has not been studied comprehensively. More specifically, when...

Read More thumbnail image: Impact of intratumoral heterogeneity of breast cancer tissue on quantitative metabolomics using highresolution magic angle spinning 1 H NMR spectroscopy

Assessing the influence of isoflurane anesthesia on cardiac metabolism using hyperpolarized [1‐ 13 C]pyruvate

Published: Dec 5, 2017

Author(s): Jonas Steinhauser, Patrick Wespi, Grzegorz Kwiatkowski, Sebastian Kozerke

Journal: NMR in Biomedicine

Isoflurane is a frequently used anesthetic in small‐animal dissolution dynamic nuclear polarization‐magnetic resonance imaging (DNP‐MRI) studies. Although the literature suggests interactions with mitochondrial metabolism, the influence of the compound on cardiac metabolism has not been assessed systematically to date. In the present study, the impact of low versus high isoflurane concentration was examined in a crossover experiment in healthy rats....

Read More thumbnail image: Assessing the influence of isoflurane anesthesia on cardiac metabolism using hyperpolarized 1 13 Cpyruvate

Complete multinuclear solid‐state NMR of metal‐organic frameworks: The case of α‐Mg‐formate

Published: Dec 5, 2017

Author(s): Bryan E. G. Lucier, Yue Zhang, Yining Huang

Journal: Concepts in Magnetic Resonance Part A

Abstract Metal‐organic frameworks (MOFs) are exciting porous materials with a growing number of applications ranging from catalysis to gas storage. Establishing logical connections between the local MOF structure and its properties is not often straightforward, however, solid‐state NMR is a sensitive probe of local structure and can be used to shed light on processes such as guest adsorption and gas motion within MOFs. As...

Read More thumbnail image: Complete multinuclear solidstate NMR of metalorganic frameworks The case of Mgformate

Recent applications of gas chromatography with high‐resolution mass spectrometry

Published: Dec 5, 2017

Author(s): Ivan Špánik, Andrea Machyňáková

Journal: Journal of Separation Science

Abstract Gas chromatography coupled to high‐resolution mass spectrometry is a powerful analytical method that combines excellent separation power of gas chromatography with improved identification based on an accurate mass measurement. These features designate gas chromatography with high‐resolution mass spectrometry as the first choice for identification and structure elucidation of unknown volatile and semi‐volatile organic...

Read More thumbnail image: Recent applications of gas chromatography with highresolution mass spectrometry

Isolation and purification of alkaloids from lotus leaves by ionic‐liquid‐modified high‐speed countercurrent chromatography

Published: Dec 5, 2017

Author(s): Nan Wu, Huihui Xie, Yingtong Fang, Yuanyuan Liu, Xingjun Xi, Qiao Chu, Genlai Dong, Tao Lan, Yun Wei

Journal: Journal of Separation Science

Abstract An effective high‐speed countercurrent chromatography method was successfully established by using ionic liquids as the modifier of the two‐phase solvent system. Adding a small amount of ionic liquids significantly shortens the separation time and improves the separation efficiency. The conditions of ionic‐liquid‐modified high‐speed countercurrent chromatography including solvent systems, types and content of added ionic...

Read More thumbnail image: Isolation and purification of alkaloids from lotus leaves by ionicliquidmodified highspeed countercurrent chromatography

Synthesis and application of a novel solid‐phase extraction adsorbent for multiresidue analysis of insecticides in water

Published: Dec 5, 2017

Author(s): Jingjing Xiong, Huizhen Li, Xue Ma, Jing You

Journal: Journal of Separation Science

Abstract A new solid‐phase adsorbent was synthesized for the simultaneous enrichment of multiple classes of trace insecticides (neonicotinoids, organophosphates, fiproles, and organochlorines) in water. The adsorbent was spherical with a diameter, surface area, average pore volume, and pore size of approximately 5 μm, 341 m2/g, 0.092 m3/g, and 2.22 nm, respectively. Extraction conditions were optimized, including water pH...

Read More thumbnail image: Synthesis and application of a novel solidphase extraction adsorbent for multiresidue analysis of insecticides in water

Analysis of the multi‐echo spin‐echo pulse sequence

Published: Dec 4, 2017

Author(s): Yuval Zur

Journal: Concepts in Magnetic Resonance Part A

Abstract The multi‐echo spin‐echo sequence is a series of operators, referred to as periodic operators. Each periodic operator consists of a free rotation (no RF), a refocusing RF pulse, and another free rotation, identical to the first one. A preparation operator that precedes the periodic operators converts the equilibrium magnetization Mz into an initial magnetization Mi. It is shown that a multi‐echo sequence is equivalent to a simple...

Read More thumbnail image: Analysis of the multiecho spinecho pulse sequence

Chemical profiling and quantification of ShenKang injection, a systematic quality control strategy using ultra high performance liquid chromatography with Q Exactive hybrid quadrupole orbitrap high‐resolution accurate mass spectrometry

Published: Dec 4, 2017

Author(s): Tanye Xu, Lihua Zuo, Zhi Sun, Peile Wang, Lin Zhou, Xiaojing Lv, Qingquan Jia, Xin Liu, Xiaofang Jiang, Zhenfeng Zhu, Jian Kang, Xiaojian Zhang

Journal: Journal of Separation Science

Abstract ShenKang injection is traditional Chinese medicine used to treat chronic renal failure in China. It is a compound preparation that consists of four herbs: Rhubarb, Salvia miltiorrhiza, Safflower and Radix Astragali. We developed an ultra high pressure liquid chromatography coupled with Q Exactive hybrid quadrupole‐orbitrap high resolution accurate mass spectrometry tandem mass spectrometry method to analyze its chemical compositions,...

Read More thumbnail image: Chemical profiling and quantification of ShenKang injection a systematic quality control strategy using ultra high performance liquid chromatography with Q Exactive hybrid quadrupole orbitrap highresolution accurate mass spectrometry

Online hyphenation of extraction, Sephadex LH‐20 column chromatography, and high‐speed countercurrent chromatography: A highly efficient strategy for the preparative separation of andrographolide from Andrographis paniculata in a single step

Published: Dec 4, 2017

Author(s): Ying‐Qi Zhang, Shan‐Shan Wang, Chao Han, Jin‐Fang Xu, Jian‐Guang Luo, Ling‐Yi Kong

Journal: Journal of Separation Science

Abstract A novel isolation strategy, online hyphenation of ultrasonic extraction, Sephadex LH‐20 column chromatography combined with high‐speed countercurrent chromatography, was developed for pure compounds extraction and purification. Andrographolide from Andrographis paniculata was achieved only in a single step purification protocol via the present strategy. The crude powder was ultrasonic extracted and extraction was pumped...

Read More thumbnail image: Online hyphenation of extraction Sephadex LH20 column chromatography and highspeed countercurrent chromatography A highly efficient strategy for the preparative separation of andrographolide from Andrographis paniculata in a single step

A real‐time in vitro assay to evaluate the release of macromolecules from liposomes

Published: Dec 4, 2017

Author(s): Himang Mujoo, John N. J. Reynolds, Ian G. Tucker

Journal: Drug Testing and Analysis

Abstract The availability of a real‐time assay to experimentally investigate the release of encapsulated proteins would be beneficial given the interest in the use of liposomes as a drug delivery vehicle. Although simple assays for small molecular weight substances exist, assays to evaluate macromolecules do not. Here we describe a method that detects the release of model macromolecules from liposomes in real time. The assay employs...

Read More thumbnail image: A realtime in vitro assay to evaluate the release of macromolecules from liposomes

Metabonomic analysis of serum reveals antifatigue effects of Yi Guan Jian on fatigue mice using gas chromatography coupled to mass spectrometry

Published: Dec 3, 2017

Author(s): Sufang Shui, Xiaorong Cai, Rongqing Huang, Bingkun Xiao, Jianyun Yang

Journal: Biomedical Chromatography

Abstract Yi Guan Jian (YGJ), one of the most commonly used traditional Chinese medicines, has been reported to possess significant antifatigue effects. However, the mechanisms underlying its antifatigue effects remain largely unresolved. In this study, a metabonomics approach, involving gas chromatography coupled to mass spectrometry and a multivariate statistical technique, was developed to estimate the extent to which YGJ...

Read More thumbnail image: Metabonomic analysis of serum reveals antifatigue effects of Yi Guan Jian on fatigue mice using gas chromatography coupled to mass spectrometry

Simultaneous determination and tissue distribution studies of four phenolic acids in rat tissue by UFLC–MS/MS after intravenous administration of salvianolic acid for injection

Published: Dec 3, 2017

Author(s): Shuang Li, Xiuman Xie, Dongxiang Li, Zhiguo Yu, Ling Tong, Yunli Zhao

Journal: Biomedical Chromatography

Abstract A rapid, simple and sensitive ultra‐fast liquid chromatography tandem mass spectrometric method was developed and validated for simultaneous determination and tissue distribution studies of rosmarinic acid, salvianolic acid D, lithospermic acid and salvianolic acid B in rats after intravenous administration of salvianolic acid for injection. The tissue homogenate samples were pretreated by protein precipitation with...

Read More thumbnail image: Simultaneous determination and tissue distribution studies of four phenolic acids in rat tissue by UFLCMSMS after intravenous administration of salvianolic acid for injection

Raman microspectroscopy of blue‐green historical beads: Comparative study of undamaged and strongly degraded samples

Published: Dec 1, 2017

Author(s): I.A. Balakhnina, N.N. Brandt, A.Y. Chikishev, A.A. Mankova, E.A. Morozova, I.G. Shpachenko, V.A. Yuryev, T.V. Yuryeva

Journal: Journal of Raman Spectroscopy

Abstract Confocal Raman microspectroscopy is used to substantially supplement existing experimental data on historical blue‐green beads with respect to the presence and distribution of potassium antimony silicate (KSS) crystals. Problem of degradation of blue‐green beads on historical artifacts accounts for topicality of the work. The reasons for possible short‐term (several years) degradation of beads and the presence of...

Read More thumbnail image: Raman microspectroscopy of bluegreen historical beads Comparative study of undamaged and strongly degraded samples
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