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Pharmacokinetic and metabolism studies of bavachinin through ultra‐high‐performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry

Published: Jun 8, 2018

Author(s): Jun Qian, Fan Xie, Yanhong Shi, Jinhang Li, Liuqiang Zhang, Yiming Li, Fujiang Guo, Rui Wang

Journal: Biomedical Chromatography

Abstract Bavachinin (BVC), one of the main bioactive prenylated flavonoids derived from Psoralea corylifolia Linn, has a wide variety of pharmacological effects, such as antiangiogenic, antitumor, antiallergic, anti‐inflammatory and antibacterial activities, especially as a pan‐peroxisome proliferator‐activated receptors agonist. A rapid and sensitive method for quantifying BVC in rat plasma was developed and validated through...

Read More thumbnail image: Pharmacokinetic and metabolism studies of bavachinin through ultrahighperformance liquid chromatography coupled with electrospray ionization tandem mass spectrometry

Probing the dynamics of dithiooxamide coordinated to gold nanoparticles using SERS

Published: Jun 8, 2018

Author(s): Daniel Grasseschi, Vitor M. Zamarion, Henrique E. Toma

Journal: Journal of Raman Spectroscopy

Abstract The substitution kinetics and specific binding modes of the dithiooxamide (dto) ligand at the metal surface have been investigated and interpreted on the light of theoretical and experimental Raman studies. By monitoring the vibrational properties of this ligand, it was shown that gold nanoparticles employed as surface‐enhanced effects (SERS) probes are strongly dependent on the coordination chemistry of the ligands at the...

Read More thumbnail image: Probing the dynamics of dithiooxamide coordinated to gold nanoparticles using SERS

Development and applications of nonlinear optical spectroscopy: 16th ECONOS/36th ECW meeting in Jena (Germany)

Published: Jun 8, 2018

Author(s): Michael Schmitt, Jürgen Popp, Johannes Kiefer, Julian Moger

Journal: Journal of Raman Spectroscopy

Read More thumbnail image: Development and applications of nonlinear optical spectroscopy 16th ECONOS36th ECW meeting in Jena Germany

Polarization‐resolved Raman modes of monoclinic SrAl 2 O 4 ceramics

Published: Jun 8, 2018

Author(s): Anderson Dias, Roberto Luiz Moreira

Journal: Journal of Raman Spectroscopy

Abstract SrAl2O4 materials were obtained by molten salt synthesis and sintered at high temperatures to produce a ceramic body suitable for polarization‐resolved Raman spectroscopy measurements. Optimized experimental conditions were employed to study the complex vibrational spectrum of these ceramics under polarized light. A reliable set of experimental bands was obtained: 69 Raman modes were in fact observed, out of the 81 bands...

Read More thumbnail image: Polarizationresolved Raman modes of monoclinic SrAl 2 O 4 ceramics

Raman spectroscopy as a powerful technique for the identification of polymers used in cast sculptures from museum collections

Published: Jun 8, 2018

Author(s): Anna Klisińska‐Kopacz, Barbara Łydżba‐Kopczyńska, Monika Czarnecka, Tomasz Koźlecki, Julio Hoyo Mélendez, Agata Mendys, Anna Kłosowska‐Klechowska, Michał Obarzanowski, Piotr Frączek

Journal: Journal of Raman Spectroscopy

Abstract The chemical identification of materials is the first step for developing and implementing recommendations for the care and display of resin cast and plastic objects in museum collections. This paper presents advantages as well as limitations of portable Raman. Therefore, a comparative analysis of portable and benchtop Raman instruments was performed in the study of materials found in the contemporary art collections of the...

Read More thumbnail image: Raman spectroscopy as a powerful technique for the identification of polymers used in cast sculptures from museum collections

Metabolomic comparison between wild Ophiocordyceps sinensis and artificial cultured Cordyceps militaris

Published: Jun 7, 2018

Author(s): Lin Chen, Yuetao Liu, Qingfeng Guo, Qingxia Zheng, Wancun Zhang

Journal: Biomedical Chromatography

Abstract A systematic study on the metabolome differences between wild Ophiocordyceps sinensis and artificial cultured Cordyceps militaris was conducted using liquid chromatography−mass spectrometry. Principal component analysis and orthogonal projection on latent structure‐discriminant analysis results showed that C. militaris grown on solid rice medium (R‐CM) and C. militaris grown on tussah pupa (T‐CM) evidently separated and individually separated from...

Read More thumbnail image: Metabolomic comparison between wild Ophiocordyceps sinensis and artificial cultured Cordyceps militaris

Capillary electrophoresis, a method for the determination of nucleic acid ligands covalently attached to quantum dots representing a donor of Förster resonance energy transfer

Published: Jun 7, 2018

Author(s): Vladimíra Datinská, Karel Klepárník, Barbora Belšánová, Marek Minárik, František Foret

Journal: Journal of Separation Science

Abstract The synthesis and determination of the structure of a Förster resonance energy transfer probe intended for the detection of specific nucleic acid sequences are described here. The probe is based on the hybridization of oligonucleotide modified quantum dots with a fluorescently labeled nucleic acid sample resulting in changes of the fluorescence emission due to the energy transfer effect. The stoichiometry distribution of...

Read More thumbnail image: Capillary electrophoresis a method for the determination of nucleic acid ligands covalently attached to quantum dots representing a donor of Forster resonance energy transfer

Middle‐Down MS is Ready to Answer Complex Questions in Chromatin Biology

Published: Jun 7, 2018

Author(s): Simone Sidoli

Journal: PROTEOMICS

Abstract Histones are the most abundant protein family in the cells of complex organisms such as mammals and, together with DNA, they define the backbone of chromatin. Histone PTMs are key players of chromatin biology, as they function as anchors for proteins that bind and modulate chromatin readout, including gene expression. Middle‐down mass spectrometry (MS) has been optimized for about 10 years to study histone N‐terminal tails,...

Read More thumbnail image: MiddleDown MS is Ready to Answer Complex Questions in Chromatin Biology

Recent trends in sorption‐based sample preparation and liquid chromatography techniques for food analysis

Published: Jun 7, 2018

Author(s): Edvaldo V. Soares Maciel, Ana Lúcia Toffoli, Fernando Mauro Lanças

Journal: ELECTROPHORESIS

Abstract The accelerated rising of the world's population increased the consumption of food, thus demanding more rigors in the control of residue and contaminants in food–based products marketed for human consumption. In view of the complexity of most food matrices, including fruits, vegetables, different types of meat, beverages, among others, a sample preparation step is important to provide more reliable results when combined...

Read More thumbnail image: Recent trends in sorptionbased sample preparation and liquid chromatography techniques for food analysis

Preparative free‐flow electrophoresis, a versatile technology complementing gradient centrifugation in the isolation of highly purified cell organelles

Published: Jun 7, 2018

Author(s): Markus Islinger, Robert Wildgruber, Alfred Völkl

Journal: ELECTROPHORESIS

Abstract Free‐flow electrophoresis (FFE) exploits differences in the overall charge of bio‐particles separating cells, organelles, macromolecules, ions, etc. according to their distinct electrophoretic mobility and isoelectric point (pI) values. Indeed, around a neutral pH organelles usually exhibit a negative surface charge, migrating in an electric field from the cathode toward the anode. Since its introduction more than five decades ago by...

Read More thumbnail image: Preparative freeflow electrophoresis a versatile technology complementing gradient centrifugation in the isolation of highly purified cell organelles

Optimization of artemisinin extraction from Artemisia annua L. with supercritical carbon dioxide + ethanol using response surface methodology

Published: Jun 7, 2018

Author(s): Ozan Nazim Ciftci, Jessica Cahyadi, Selma E. Guigard, Marleny D. A. Saldaña

Journal: ELECTROPHORESIS

Abstract Malaria is a high priority life‐threatening public health concern in developing countries, and therefore there is a growing interest to obtain artemisinin for the production of artemisinin‐based combination therapy products. In this study, artemisinin was extracted from the Artemisia annua L. plant using supercritical carbon dioxide (SC‐CO2) modified with ethanol. Response surface methodology based on central composite rotatable design...

Read More thumbnail image: Optimization of artemisinin extraction from Artemisia annua L_ with supercritical carbon dioxide  ethanol using response surface methodology

A combined experimental and theoretical approach to determine X‐ray atomic fundamental quantities of tin

Published: Jun 7, 2018

Author(s): Y. Ménesguen, M.‐C. Lépy, J. M. Sampaio, J. P. Marques, F. Parente, M. Guerra, P. Indelicato, J. P. Santos, P. Hönicke, B. Beckhoff

Journal: X-Ray Spectrometry

The knowledge of atomic fundamental parameters, such as the mass attenuation coefficients or fluorescence yields with low uncertainties, is of decisive importance in elemental quantification involving X‐ray fluorescence analysis techniques. For example, several databases giving the mass attenuation coefficients are accessible and frequently used within a large community of users. These compilations are most often in good agreement for...

Read More thumbnail image: A combined experimental and theoretical approach to determine Xray atomic fundamental quantities of tin

Investigation of the pigment use in the Tomb of the Reliefs and other tombs in the Etruscan Banditaccia Necropolis

Published: Jun 7, 2018

Author(s): Matthias Alfeld, Cecilia Baraldi, Maria Cristina Gamberini, Philippe Walter

Journal: X-Ray Spectrometry

The pigment use in the Tomb of the Reliefs (fourth century BC) and four other tombs (seventh to fourth century BC) in the Etruscan Banditaccia Necropolis near Cerveteri, Italy, has been investigated. We made use of X‐ray fluorescence (XRF) and Raman spot analysis, XRF imaging, infrared luminescence and photography supported by Dstretch contrast enhancement. We identified the use of haematite, goethite, calcite, carbon black, manganese...

Read More thumbnail image: Investigation of the pigment use in the Tomb of the Reliefs and other tombs in the Etruscan Banditaccia Necropolis

Label‐free and non‐invasive BS‐SERS detection of liver cancer based on the solid device of silver nanofilm

Published: Jun 7, 2018

Author(s): Renming Liu, Yang Xiong, Yan Guo, Minzhen Si, Weiyue Tang

Journal: Journal of Raman Spectroscopy

Abstract Rapid and accurate diagnosis of cancers at early stage is clearly desirable, because it provides possibilities to cure the cancers in next treatments. Cancers at early stage usually occur and develop at a molecule level; however, it remains challenging for traditional methods to screen them timely. Here, the capability of using human blood serum surface‐enhanced Raman scattering (BS‐SERS) spectroscopy for label‐free,...

Read More thumbnail image: Labelfree and noninvasive BSSERS detection of liver cancer based on the solid device of silver nanofilm

Stable Protein Gel Storage in Acetonitrile for Mass Spectrometric Analysis

Published: Jun 6, 2018

Author(s): Yuxin Chen, Sen Wang, Jia Jia, Xinyu Tian, Hongpan Xu, Mingzhe Ning, Bing Bai

Journal: PROTEOMICS

Abstract Long‐term storage of protein samples for transportation is a challenge in the field of mass spectrometric analysis because the low temperature condition is not easy to be maintained. Here we introduce a simple method to preserve proteins at room temperature for at least one month. In this method, the protein sample is run shortly into a polyacrylamide gel which is then excised after Coomassie staining. The protein gel band...

Read More thumbnail image: Stable Protein Gel Storage in Acetonitrile for Mass Spectrometric Analysis

An Integrated Proteomic Approach Uncovers Novel Substrates and Functions of the Lon Protease in Escherichia coli

Published: Jun 6, 2018

Author(s): Jan Arends, Marcena Griego, Nikolas Thomanek, Claudia Lindemann, Blanka Kutscher, Helmut E. Meyer, Franz Narberhaus

Journal: PROTEOMICS

Abstract Controlling the cellular abundance and proper function of proteins by proteolysis is a universal process in all living organisms. In Escherichia coli, the ATP‐dependent Lon protease is crucial for protein quality control and regulatory processes. To understand how diverse substrates are selected and degraded, unbiased global approaches are needed. We employed a quantitative Super‐SILAC (stable isotope labeling with amino...

Read More thumbnail image: An Integrated Proteomic Approach Uncovers Novel Substrates and Functions of the Lon Protease in Escherichia coli

Metabolic profiles of neratinib in rat by using ultra‐high‐performance liquid chromatography coupled with diode array detector and Q‐Exactive Orbitrap tandem mass spectrometry

Published: Jun 5, 2018

Author(s): Wen Liu, Sha Li, Yangke Wu, Xiao Yan, Y.‐M. Zhu, J.‐H. Huang, Zhuo Chen

Journal: Biomedical Chromatography

Abstract Neratinib is a tyrosine kinase inhibitor that has been approved by the US Food and Drug Administration for the treatment of breast cancer. However, its metabolism remains unknown. This study was carried out to investigate the in vitro and in vivo metabolism of neratinib using an UHPLC‐DAD‐Q Exactive Orbitrap‐MS instrument with dd‐MS2 on‐line data acquisition mode. The post‐acquisition data was processed using MetWorks software. Under the current...

Read More thumbnail image: Metabolic profiles of neratinib in rat by using ultrahighperformance liquid chromatography coupled with diode array detector and QExactive Orbitrap tandem mass spectrometry

Evaluation of needle trap micro‐extraction and solid‐phase micro‐extraction: Obtaining comprehensive information on volatile emissions from in vitro cultures

Published: Jun 5, 2018

Author(s): Peter Oertel, Andreas Bergmann, Sina Fischer, Phillip Trefz, Anne Küntzel, Petra Reinhold, Heike Köhler, Jochen K. Schubert, Wolfram Miekisch

Journal: Biomedical Chromatography

Abstract Volatile organic compounds (VOCs) emitted from in vitro cultures may reveal information on species and metabolism. Owing to low nmol L−1 concentration ranges, pre‐concentration techniques are required for gas chromatography–mass spectrometry (GC–MS) based analyses. This study was intended to compare the efficiency of established micro‐extraction techniques – solid‐phase micro‐extraction (SPME) and needle‐trap micro‐extraction (NTME) –...

Read More thumbnail image: Evaluation of needle trap microextraction and solidphase microextraction Obtaining comprehensive information on volatile emissions from in vitro cultures

Chemical Proteomics of Host–Microbe Interactions

Published: Jun 5, 2018

Author(s): Megan H Wright

Journal: PROTEOMICS

Abstract The dynamic proteome plays numerous roles in the interactions of microbes—whether they are invading pathogens or symbiotic organisms—and their hosts. Host and microbe sense, respond, and manipulate each other's biology via a multitude of mechanisms, resulting in alterations in protein expression or posttranslational modification that influence protein localization, activity, or binding partners. The intrinsic, temporal, and...

Read More thumbnail image: Chemical Proteomics of HostMicrobe Interactions

Neuroproteins in Cancer: Assumed Bystanders Become Culprits

Published: Jun 5, 2018

Author(s): Xiang Li, Matt D. Dun, Sam Faulkner, Hubert Hondermarck

Journal: PROTEOMICS

Abstract Recent breakthrough discoveries have highlighted the stimulatory role of nerves in cancer initiation and progression, through the release of neurotransmitters and growth factors by nerve terminals in the tumor microenvironment. Intriguingly, neuroproteins such as neuronal membrane proteins, synaptic proteins, neurotransmitters, and neurotrophic growth factors as well as their corresponding receptors, to name only a few, are...

Read More thumbnail image: Neuroproteins in Cancer Assumed Bystanders Become Culprits
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