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Electrokinetic motion of a spherical micro particle at an oil−water interface in microchannel

Published: Oct 4, 2017

Author(s): Chengfa Wang, Mengqi Li, Yongxin Song, Xinxiang Pan, Dongqing Li

Journal: ELECTROPHORESIS

Abstract The electrokinetic motion of a negatively charged spherical particle at an oil−water interface in a microchannel is numerically investigated and analyzed in this paper. A three−dimensional (3D) transient numerical model is developed to simulate the particle electrokinetic motion. The channel wall, the surface of the particle and the oil−water interface are all considered negatively charged. The effects of the direct current...

Read More thumbnail image: Electrokinetic motion of a spherical micro particle at an oilwater interface in microchannel

Organic polymer‐based monolithic stationary phases with incorporated nanostructured materials for HPLC and CEC

Published: Oct 4, 2017

Author(s): Nisansala Ganewatta, Ziad El Rassi

Journal: ELECTROPHORESIS

Abstract This review article is concerned with the recent advances made in the field of organic polymer‐based monoliths with incorporated nanostructured materials (NSMs) for use in liquid chromatography and capillary electrochromatography. It covers the pertinent literature published over the last 7–8 years with a total of 56 references. The present article has two distinct parts: one major part encompassing “traditional” organic...

Read More thumbnail image: Organic polymerbased monolithic stationary phases with incorporated nanostructured materials for HPLC and CEC

Anti‐inflammatory activities and glycerophospholipids metabolism in KLA‐stimulated RAW 264.7 macrophage cells by diarylheptanoids from the rhizomes of Alpinia officinarum

Published: Oct 2, 2017

Author(s): Guogai Zhang, Lifang Zhao, Jiancheng Zhu, Yifan Feng, Xia Wu

Journal: Biomedical Chromatography

Abstract Alpinia officinarum is used for its anti‐inflammatory activity historically in China. Diarylheptanoids isolated from A. officinarum play important biological roles in the prevention and treatment of inflammatory disorders. Seven diarylheptanoids (1–7) were isolated from A. officinarum. The cell viabilities and anti‐inflammatory activities of diarylheptanoids were evaluated by MTT assay and tumor necrosis factor‐α production in...

Read More thumbnail image: Antiinflammatory activities and glycerophospholipids metabolism in KLAstimulated RAW 264_7 macrophage cells by diarylheptanoids from the rhizomes of Alpinia officinarum

Simultaneous determination of baicalin, baicalein, wogonoside, wogonin, scutellarin, berberine, coptisine, ginsenoside Rb1 and ginsenoside Re of Banxia xiexin decoction in rat plasma by LC–MS/MS and its application to a pharmacokinetic study

Published: Oct 2, 2017

Author(s): Ying Wang, Yifan Zhang, Juan Xiao, Ranchi Xu, Qiangli Wang, Xinhong Wang

Journal: Biomedical Chromatography

Abstract A rapid and high‐sensitivity liquid chromatography/tandem mass spectrometry (LC/MS/MS) method was developed for simultaneous determination of nine active constituents (baicalin, baicalein, wogonoside, wogonin, scutellarin, berberine, coptisine, ginsenoside Rb1 and ginsenoside Re) in rat plasma after oral administration of Banxia xiexin decoction (BXD). Biological samples were processed wtih acetone–ethyl acetate (4:1, v/v)....

Read More thumbnail image: Simultaneous determination of baicalin baicalein wogonoside wogonin scutellarin berberine coptisine ginsenoside Rb1 and ginsenoside Re of Banxia xiexin decoction in rat plasma by LCMSMS and its application to a pharmacokinetic study

Simple determination of betaine, l ‐carnitine and choline in human urine using self‐packed column and column‐switching ion chromatography with nonsuppressed conductivity detection

Published: Oct 2, 2017

Author(s): Dan Wei, Yan Zhu, Ming Guo

Journal: Biomedical Chromatography

Abstract A sequential online extraction, clean‐up and separation system for the determination of betaine, l‐carnitine and choline in human urine using column‐switching ion chromatography with nonsuppressed conductivity detection was developed in this work. A self‐packed pretreatment column (50 × 4.6 mm, i.d.) was used for the extraction and clean‐up of betaine, l‐carnitine and choline. The separation was achieved using self‐packed cationic...

Read More thumbnail image: Simple determination of betaine l carnitine and choline in human urine using selfpacked column and columnswitching ion chromatography with nonsuppressed conductivity detection

Overcoming interference of plasma phospholipids using HybridSPE for the determination of trimetazidine by UPLC–MS/MS

Published: Oct 2, 2017

Author(s): Pravin G. Vanol, Manish Yadav, Mallika Sanyal, Priyanka A. Shah, Pranav S. Shrivastav

Journal: Biomedical Chromatography

Abstract An improved, precise and reliable ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method has been developed for the quantification of trimetazidine, using trimetazidine‐d8 as the internal standard (IS). Interference owing to plasma phospholipids during sample preparation was overcome using a hybrid solid‐phase extraction–phospholipid ultra cartridge. The mean extraction recovery of...

Read More thumbnail image: Overcoming interference of plasma phospholipids using HybridSPE for the determination of trimetazidine by UPLCMSMS

Intergrated metabonomic study of the effects of Guizhi Fuling capsule intervention on primary dysmenorrheal using RP‐UPLC–MS complementary with HILIC‐UPLC–MS technique

Published: Oct 2, 2017

Author(s): Lang Lang, Zhaorui Meng, Lan Sun, Wei Xiao, Longshan Zhao, Zhili Xiong

Journal: Biomedical Chromatography

Abstract Guizhi Fuling capsule (GFC), developed from the traditional Chinese prescription of Guizhi Fuling Wan, has been commonly used for the treatment of primary dysmenorrhea (PD). However, the intervention effective mechanism in vivo has not been well elucidated. In this study, an integrated plasma metabonomic strategy based on RP‐UPLC‐MS coupled with HILIC‐UPLC‐MS technique has been developed to investigate the global therapeutic effects and...

Read More thumbnail image: Intergrated metabonomic study of the effects of Guizhi Fuling capsule intervention on primary dysmenorrheal using RPUPLCMS complementary with HILICUPLCMS technique

Real‐time metabolite monitoring of glucose‐fed Clostridium acetobutylicum fermentations using Raman assisted metabolomics

Published: Oct 2, 2017

Author(s): Theresah N.K. Zu, Sanchao Liu, Elliot S. Gerlach, Katherine L. Germane, Matthew D. Servinsky, David M. Mackie, Christian J. Sund

Journal: Journal of Raman Spectroscopy

Abstract Data obtained from in situ Raman spectroscopy probes and high‐performance liquid chromatography (HPLC) analysis were applied together with chemometrics to build partial least squares models of metabolite concentrations for the industrially relevant organism Clostridium acetobutylicum. Models were built for predominant products (acetic acid, butyric acid, and butanol) of C. acetobutylicum cultures grown on glucose as a substrate....

Read More thumbnail image: Realtime metabolite monitoring of glucosefed Clostridium acetobutylicum fermentations using Raman assisted metabolomics

Raman mapping of the S 3 chromophore in degraded ultramarine blue paints

Published: Oct 2, 2017

Author(s): Eleanor Cato, Nadim Scherrer, Ester S.B. Ferreira

Journal: Journal of Raman Spectroscopy

Abstract A specific case of degradation was observed in synthetic ultramarine paint within 3 paintings from the early 20th century, manifesting as an intricate pattern of white lines criss‐crossing the blue paint surface. Raman spectroscopy can be performed directly on untreated sample surfaces and is sensitive to the colour components in ultramarine (S3− and S2− chromophores). This method was chosen to map the chromophore intensity...

Read More thumbnail image: Raman mapping of the S 3  chromophore in degraded ultramarine blue paints

The identification and analytical characterization of 2,2′‐difluorofentanyl

Published: Oct 2, 2017

Author(s): Cuimei Liu, Tao Li, Yu Han, Zhendong Hua, Wei Jia, Zhenhua Qian

Journal: Drug Testing and Analysis

Abstract New psychoactive substances (NPS) have expanded their distribution and become widely available in the global market in recent years. The illicit use of fentanyl and its analogs has become an important worldwide concern linked to their high potency and risk of fatal overdose. This study describes the analytical characterization of a new fentanyl derivative N‐(1‐(2‐fluorophenethyl)‐4‐piperidinyl)‐N‐(2‐fluorophenyl)propionamide...

Read More thumbnail image: The identification and analytical characterization of 22difluorofentanyl

Simultaneous construction of dual Borgen plots. I: The case of noise‐free data

Published: Oct 2, 2017

Author(s): Mathias Sawall, Annekathrin Jürß, Henning Schröder, Klaus Neymeyr

Journal: Journal of Chemometrics

Abstract In 1985, Borgen and Kowalski [DOI:10.1016/S0003‐2670(00)84361‐5] introduced a geometric construction algorithm for the regions of feasible nonnegative factorizations of spectral data matrices for three‐component systems. The resulting Borgen plots represent the so‐called area of feasible solutions (AFS). The AFS can be computed either for the spectral factor or for the factor of the concentration profiles. In the latter...

Read More thumbnail image: Simultaneous construction of dual Borgen plots_ I The case of noisefree data

Characterization and stratification of prostate lesions based on comprehensive multiparametric MRI using detailed whole‐mount histopathology as a reference standard

Published: Sep 29, 2017

Author(s): Olga Starobinets, Jeffry P. Simko, Kyle Kuchinsky, John Kornak, Peter R. Carroll, Kirsten L. Greene, John Kurhanewicz, Susan M. Noworolski

Journal: NMR in Biomedicine

The purpose of this study was to characterize prostate cancer (PCa) based on multiparametric MR (mpMR) measures derived from MRI, diffusion, spectroscopy, and dynamic contrast‐enhanced (DCE) MRI, and to validate mpMRI in detecting PCa and predicting PCa aggressiveness by correlating mpMRI findings with whole‐mount histopathology. Seventy‐eight men with untreated PCa received 3 T mpMR scans prior to radical prostatectomy. Cancerous...

Read More thumbnail image: Characterization and stratification of prostate lesions based on comprehensive multiparametric MRI using detailed wholemount histopathology as a reference standard

Investigation of the contribution of total creatine to the CEST Z ‐spectrum of brain using a knockout mouse model

Published: Sep 29, 2017

Author(s): Lin Chen, Haifeng Zeng, Xiang Xu, Nirbhay N. Yadav, Shuhui Cai, Nicolaas A. Puts, Peter B. Barker, Tong Li, Robert G. Weiss, Peter C.M. Zijl, Jiadi Xu

Journal: NMR in Biomedicine

The current study aims to assign and estimate the total creatine (tCr) signal contribution to the Z‐spectrum in mouse brain at 11.7 T. Creatine (Cr), phosphocreatine (PCr) and protein phantoms were used to confirm the presence of a guanidinium resonance at this field strength. Wild‐type (WT) and knockout mice with guanidinoacetate N‐methyltransferase deficiency (GAMT−/−), which have low Cr and PCr concentrations in the brain, were used to assign the tCr ...

Read More thumbnail image: Investigation of the contribution of total creatine to the CEST Z spectrum of brain using a knockout mouse model

The mechanical properties of plasma‐treated carbon fiber reinforced PA6 composites with CNT

Published: Sep 29, 2017

Author(s): Qiuxiang Chang, Haojie Zhao, Runqin He

Journal: Surface and Interface Analysis

The aim of this work is the evaluation of the effects of plasma treatment and the addition of CNT on the mechanical properties of carbon fibre/PA6 composite. A powder impregnation process with integrated inline continuous plasma of carbon fibers was used to produce CF/PA6 composite. CF/PA6 composite was processed into test laminates by compression moulding, and interface dominated composite properties were studied. The tensile and impact...

Read More thumbnail image: The mechanical properties of plasmatreated carbon fiber reinforced PA6 composites with CNT

Time‐of‐flight secondary ion mass spectrometry analysis of paint craters

Published: Sep 29, 2017

Author(s): Heather L. Bloomfield, Heng‐Yong Nie

Journal: Surface and Interface Analysis

Localized sudden changes in the surface energy of a surface to be painted are commonly held responsible for causing paint craters. However, it is not necessarily an easy task to identify the material(s) that produced the defects. Automotive paint cratering, when it happens, often requires immediate identification of its causes because the product line may have to be shut down until the problem is solved. For the past 18 years,...

Read More thumbnail image: Timeofflight secondary ion mass spectrometry analysis of paint craters

Influences of acid and heat treatments on the structure and water vapor adsorption property of natural zeolite

Published: Sep 29, 2017

Author(s): Cheng Wang, Liyun Cao, Jianfeng Huang

Journal: Surface and Interface Analysis

Natural zeolite was first acid treated and then heat treated. The influences of acid and heat treatments on the structure and water vapor adsorption property of natural zeolite were investigated. X‐ray photoelectron spectroscopy (XPS), X‐ray diffraction (XRD), thermogravimetric analysis (TG), and Brunauer‐Emmett‐Teller (BET) surface areas were employed to investigate the structure changes of the zeolite samples. Water vapor adsorption...

Read More thumbnail image: Influences of acid and heat treatments on the structure and water vapor adsorption property of natural zeolite

Electrical, optical, and structural characterization of p‐type N ‐doped S n O thin films prepared by thermal oxidation of sputtered SnNx thin films

Published: Sep 29, 2017

Author(s): A. Garzon‐Fontecha, W. De La Cruz, M. Quevedo

Journal: Surface and Interface Analysis

We present a study of electrical and optical properties of nitrogen‐doped tin oxide thin films deposited on glass by the DC Magnetron Sputtering method. The deposition conditions to obtain p‐type thin films were a relative partial pressure between 7% and 11% (N2 and/or O2), a total working pressure of 1.8 mTorr and a plasma power of 30 W. The deposited thin films were oxidized after annealing at 250°C for 30 minutes. X‐ray...

Read More thumbnail image: Electrical optical and structural characterization of ptype N doped S n O thin films prepared by thermal oxidation of sputtered SnNx thin films

Quantitative analysis of trace levels of surface contamination by X‐ray photoelectron spectroscopy. Part I: Statistical uncertainty near the detection limit

Published: Sep 29, 2017

Author(s): Shannon B. Hill, Nadir S. Faradzhev, Cedric J. Powell

Journal: Surface and Interface Analysis

We discuss the problem of quantifying common sources of statistical uncertainties for analyses of trace levels of surface contamination by using X‐ray photoelectron spectroscopy. We examine the propagation of error for peak‐area measurements by using common forms of linear and polynomial background subtraction including the correlation of points used to determine both background and peak areas. This correlation has been neglected in...

Read More thumbnail image: Quantitative analysis of trace levels of surface contamination by Xray photoelectron spectroscopy_ Part I Statistical uncertainty near the detection limit

An eigenvalue approach for the automatic scaling of unknowns in model‐based reconstructions: Application to real‐time phase‐contrast flow MRI

Published: Sep 28, 2017

Author(s): Zhengguo Tan, Thorsten Hohage, Oleksandr Kalentev, Arun A. Joseph, Xiaoqing Wang, Dirk Voit, K. Dietmar Merboldt, Jens Frahm

Journal: NMR in Biomedicine

Abstract The purpose of this work is to develop an automatic method for the scaling of unknowns in model‐based nonlinear inverse reconstructions and to evaluate its application to real‐time phase‐contrast (RT‐PC) flow magnetic resonance imaging (MRI). Model‐based MRI reconstructions of parametric maps which describe a physical or physiological function require the solution of a nonlinear inverse problem, because the list of unknowns...

Read More thumbnail image: An eigenvalue approach for the automatic scaling of unknowns in modelbased reconstructions Application to realtime phasecontrast flow MRI

Diffusion parameter mapping with the combined intravoxel incoherent motion and kurtosis model using artificial neural networks at 3 T

Published: Sep 28, 2017

Author(s): Marco Bertleff, Sebastian Domsch, Sebastian Weingärtner, Jascha Zapp, Kieran O'Brien, Markus Barth, Lothar R. Schad

Journal: NMR in Biomedicine

Artificial neural networks (ANNs) were used for voxel‐wise parameter estimation with the combined intravoxel incoherent motion (IVIM) and kurtosis model facilitating robust diffusion parameter mapping in the human brain. The proposed ANN approach was compared with conventional least‐squares regression (LSR) and state‐of‐the‐art multi‐step fitting (LSR‐MS) in Monte‐Carlo simulations and in vivo in terms of estimation accuracy and...

Read More thumbnail image: Diffusion parameter mapping with the combined intravoxel incoherent motion and kurtosis model using artificial neural networks at 3T
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