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Determination of 15 polycyclic aromatic hydrocarbons in aquatic products by solid‐phase extraction and GC–MS

Published: Apr 3, 2018

Author(s): Qiying Liu, Yuanming Guo, Xiumei Sun, Qing Hao, Xin Cheng, Lu Zhang

Journal: Journal of Separation Science

Abstract We propose a method for the simultaneous determination of 15 kinds of polycyclic aromatic hydrocarbons in marine samples (muscle) employing gas chromatography with mass spectrometry after saponification with ultrasound‐assisted extraction and solid‐phase extraction. The experimental conditions were optimized by the response surface method. In addition, the effects of different lyes and extractants on polycyclic aromatic...

Read More thumbnail image: Determination of 15 polycyclic aromatic hydrocarbons in aquatic products by solidphase extraction and GCMS

Fiber‐in‐tube solid‐phase microextraction of caffeine as a molecular tracer in wastewater by electrochemically deposited layered double hydroxide

Published: Apr 3, 2018

Author(s): Maryam Lashgari, Yadollah Yamini

Journal: Journal of Separation Science

Abstract Modified stainless‐steel wires with a layer of polyaniline conductive polymer were coated by electrochemical deposition with Zn/Al layered double hydroxide to make solid‐phase microextraction fibers. The coating layer was also electrochemically deposited on the inner surface of a stainless‐steel tube. Then, ten prepared fibers were put inside the inner coated tube to make a fiber‐in‐tube solid phase microextraction device....

Read More thumbnail image: Fiberintube solidphase microextraction of caffeine as a molecular tracer in wastewater by electrochemically deposited layered double hydroxide

Temperature‐controlled liquid–liquid microextraction combined with high‐performance liquid chromatography for the simultaneous determination of diazinon and fenitrothion in water and fruit juice samples

Published: Apr 3, 2018

Author(s): Alireza Bazmandegan‐Shamili, Shayessteh Dadfarnia, Ali Mohammad Haji Shabani, Masoud Rohani Moghadam, Mahboubeh Saeidi

Journal: Journal of Separation Science

Abstract A simple, environmentally benign, and rapid method based on temperature‐controlled liquid–liquid microextraction using a deep eutectic solvent was developed for the simultaneous extraction/preconcentration of diazinon and fenitrothion. The method involved the addition of deep eutectic solvent to the aqueous sample followed by heating the mixture in a 75°C water bath until the solvent was completely dissolved in the aqueous...

Read More thumbnail image: Temperaturecontrolled liquidliquid microextraction combined with highperformance liquid chromatography for the simultaneous determination of diazinon and fenitrothion in water and fruit juice samples

Enantioselective capillary electrophoresis provides insight into the phase II metabolism of ketamine and its metabolites in vivo and in vitro

Published: Apr 3, 2018

Author(s): Friederike A. Sandbaumhüter, Wolfgang Thormann

Journal: ELECTROPHORESIS

Abstract Glucuronidation catalyzed by uridine‐5′‐diphospho‐glucuronosyl‐transferases (UGTs) is the most important reaction in phase II metabolism of drugs and other compounds. O‐glucuronidation is more common than N‐glucuronidation. The anesthetic, analgesic and antidepressive drug ketamine is metabolized in phase I by cytochrome P450 enzymes to norketamine, hydroxynorketamine (HNK) diastereomers and dehydronorketamine (DHNK)....

Read More thumbnail image: Enantioselective capillary electrophoresis provides insight into the phase II metabolism of ketamine and its metabolites in vivo and in vitro

DNA translocation through polyelectrolyte‐modified nanopores: An analytical approximation

Published: Apr 3, 2018

Author(s): Pradipta Kr. Das

Journal: ELECTROPHORESIS

Abstract An analytical model for the electrophoretic speed of DNA translocating through nanopore functionalized with polyelectrolyte (PE) brush is developed for the first time. The electrophoretic speed depends on DNA surface potential, applied electric field, viscosity, and permittivity of solution along with velocity and electrostatic potential at liquid–polyelectrolyte layer (PEL) interface where the interface seemed to behave...

Read More thumbnail image: DNA translocation through polyelectrolytemodified nanopores An analytical approximation

Method for the simultaneous determination of monoaromatic and polycyclic aromatic hydrocarbons in industrial effluents using dispersive liquid–liquid microextraction with gas chromatography–mass spectrometry

Published: Apr 3, 2018

Author(s): Patrycja Makoś, André Fernandes, Grzegorz Boczkaj

Journal: Journal of Separation Science

Abstract We present a new method for simultaneous determination of 22 monoaromatic and polycyclic aromatic hydrocarbons in postoxidative effluents from the production of petroleum bitumen using dispersive liquid–liquid microextraction coupled to gas chromatography and mass spectrometry. The eight extraction parameters including the type and volume of extraction and disperser solvent, pH, salting out effect, extraction, and...

Read More thumbnail image: Method for the simultaneous determination of monoaromatic and polycyclic aromatic hydrocarbons in industrial effluents using dispersive liquidliquid microextraction with gas chromatographymass spectrometry

Highly sensitive VOC gas sensor employing deep cooling of SERS film

Published: Apr 3, 2018

Author(s): Myoung‐Kyu Oh, Ranjit De, Sang‐Youp Yim

Journal: Journal of Raman Spectroscopy

Abstract The potential of surface‐enhanced Raman spectroscopy (SERS) as a highly sensitive and selective gas sensor was investigated experimentally. Especially, the relation between the temperature of a SERS film and gas adsorption or signal intensity was observed systemically and quantitatively, from which the enhancement of gas adsorption and signal intensity by up to 40 times was observed with the SERS film temperature of approx....

Read More thumbnail image: Highly sensitive VOC gas sensor employing deep cooling of SERS film

A sensitive LC–MS/MS method for simultaneous determination of cabozantinib and its metabolite cabozantinib N ‐oxide in rat plasma and its application in a pharmacokinetic study

Published: Apr 2, 2018

Author(s): Lian‐jie Ren, Hua‐jing Wu, Li‐han Sun, Xue Xu, Li‐ying Mo, Lei Zhang, Jun‐ying Zhang, Chun‐yong Wu

Journal: Biomedical Chromatography

Abstract Cabozantinib (CBZ) is used for the treatment of progressive, metastatic medullary thyroid cancer. Its major oxidative metabolite is cabozantinib N‐oxide (CBN), which contains a structural alert associated with mutagenicity, yet the pharmacokinetics studies lack the simultaneous investigation of CBN and dose proportionality. In the current study a simple LC–MS/MS method was developed and validated for the simultaneous...

Read More thumbnail image: A sensitive LCMSMS method for simultaneous determination of cabozantinib and its metabolite cabozantinib N oxide in rat plasma and its application in a pharmacokinetic study

Determination of metoserpate, buquinolate, and diclofenac in pork, eggs, and milk using liquid chromatography–tandem mass spectrometry

Published: Apr 2, 2018

Author(s): Jin‐A Park, A. M. Abd El‐Aty, Weijia Zheng, Seong‐Kwan Kim, Jeong‐min Choi, Ahmet Hacımüftüoğlu, Jae‐Han Shim, Ho‐Chul Shin

Journal: Biomedical Chromatography

Abstract In this work, a method was developed for the simultaneous determination of residual metoserpate, buquinolate and diclofenac in pork, milk, and eggs. Samples were extracted with 0.1% formic acid in acetonitrile, defatted with n‐hexane, and filtered prior to analysis using liquid chromatography–tandem mass spectrometry. The analytes were separated on a C18 column using 0.1% acetic acid and methanol as the mobile phase. The matrix‐matched...

Read More thumbnail image: Determination of metoserpate buquinolate and diclofenac in pork eggs and milk using liquid chromatographytandem mass spectrometry

Lipophilicity evaluation of some thiazolyl‐1,3,4‐oxadiazole derivatives with antifungal activity

Published: Apr 2, 2018

Author(s): Cristina Ioana Stoica, Ioana Ionuț, Laurian Vlase, Brîndușa Tiperciuc, Gabriel Marc, Smaranda Oniga, Cătălin Araniciu, Ovidiu Oniga

Journal: Biomedical Chromatography

Abstract The chromatographic behavior of a series of thiazolyl‐1,3,4‐oxadiazoles with antifungal activity was studied by reverse‐phase thin‐layer chromatography (RP‐TLC). The lipophilicity parameters derived from RP‐TLC were correlated with the data derived from liquid‐chromatography mass‐spectrometry. Good linear relationships were observed between the chromatographic lipophilicity parameters and the theoretical lipophilicity...

Read More thumbnail image: Lipophilicity evaluation of some thiazolyl134oxadiazole derivatives with antifungal activity

Simultaneous determination of evodiamine and its four metabolites in rat plasma by LC–MS/MS and its application to a pharmacokinetic study

Published: Apr 2, 2018

Author(s): Cuiyun Wang, Fang Yue, Guangfeng Ai, Jie Yang

Journal: Biomedical Chromatography

Abstract A simple and sensitive liquid chromatography tandem mass spectrometry method was validated for simultaneous quantification of evodiamine and its metabolites 10‐hydroxyevodiamine (M1), 18‐hydroxyevodiamine (M2), 10‐hydroxyevodiamine‐glucuronide (M3) and 18‐hydroxy‐ evodiamine‐glucuronide (M4) in rat plasma for the first time. The analytes were extracted with acetonitrile and separated on a C18 column within 3 min. The...

Read More thumbnail image: Simultaneous determination of evodiamine and its four metabolites in rat plasma by LCMSMS and its application to a pharmacokinetic study

Enantioseparation and determination of dufulin enantiomers in cucumber and soil by chiral liquid chromatography–tandem mass spectrometry

Published: Apr 2, 2018

Author(s): Haizhen Zhang, Min Huang, Weiwei Yu, A'wei Zhang, Kankan Zhang, Deyu Hu

Journal: Biomedical Chromatography

Abstract A simple and rapid method for enantioselective determination of dufulin in cucumber and soil was developed by liquid chromatography with tandem mass spectrometry. The enantiomers were separated on a Superchiral S‐OD chiral cellulose tris(3,5‐dimethylphenylcarbamate) column at 20°C, with a mixture of acetonitrile and water (0.1% formic acid; 52:48, v/v) as mobile phase at a flow rate of 0.65 mL/min. The pretreatment conditions were...

Read More thumbnail image: Enantioseparation and determination of dufulin enantiomers in cucumber and soil by chiral liquid chromatographytandem mass spectrometry

Quantification of amlodipine and atorvastatin in human plasma by UPLC–MS/MS method and its application to a bioequivalence study

Published: Apr 2, 2018

Author(s): Mamdouh R. Rezk, Kamal A. Badr

Journal: Biomedical Chromatography

Abstract A robust, rapid and sensitive UPLC–MS/MS method has been developed, optimized and validated for the determination of amlodipine (AML) and atorvastatin (ATO) in human plasma using eplerenone as an internal standard (IS). Multiple‐reaction monitoring in positive electrospray ionization mode was utilized in Xevo TQD LC–MS/MS. Double extraction was used in sample preparation using diethyl ether and ethyl acetate. The prepared...

Read More thumbnail image: Quantification of amlodipine and atorvastatin in human plasma by UPLCMSMS method and its application to a bioequivalence study

Oscillating gradient diffusion kurtosis imaging of normal and injured mouse brains

Published: Mar 30, 2018

Author(s): Dan Wu, Qiang Li, Frances J. Northington, Jiangyang Zhang

Journal: NMR in Biomedicine

Recent advances in diffusion MRI employ multiple diffusion encoding schemes with varying diffusion direction, weighting, and diffusion time to investigate specific microstructural properties in biological tissues. In this study, we examined time‐dependent diffusion kurtosis contrast in adult mouse brains and in neonatal mouse brains after hypoxic–ischemic (HI) injury. In vivo diffusion kurtosis maps were acquired with a short diffusion time using an...

Read More thumbnail image: Oscillating gradient diffusion kurtosis imaging of normal and injured mouse brains

Analysis and improvement of motion encoding in magnetic resonance elastography

Published: Mar 30, 2018

Author(s): Christian Guenthner, Jurgen Henk Runge, Ralph Sinkus, Sebastian Kozerke

Journal: NMR in Biomedicine

Magnetic resonance elastography (MRE) utilizes phase contrast magnetic resonance imaging (MRI), which is phase locked to externally generated mechanical vibrations, to measure the three‐dimensional wave displacement field. At least four measurements with linear‐independent encoding directions are necessary to correct for spurious phase contributions if effects from imaging gradients are non‐negligible. In MRE, three encoding schemes have...

Read More thumbnail image: Analysis and improvement of motion encoding in magnetic resonance elastography

Cerebral perfusion characteristics show differences in younger versus older children with sickle cell anaemia: Results from a multiple‐inflow‐time arterial spin labelling study

Published: Mar 30, 2018

Author(s): Jamie M. Kawadler, Patrick W. Hales, Simon Barker, Timothy C. S. Cox, Fenella J. Kirkham, Chris A. Clark

Journal: NMR in Biomedicine

Sickle cell anaemia (SCA) is associated with chronic anaemia and oxygen desaturation, which elevate cerebral blood flow (CBF) and increase the risk of neurocognitive complications. Arterial spin labelling (ASL) provides a methodology for measuring CBF non‐invasively; however, ASL techniques using only a single inflow time are not sufficient to fully characterize abnormal haemodynamic behaviour in SCA. This study investigated haemodynamic...

Read More thumbnail image: Cerebral perfusion characteristics show differences in younger versus older children with sickle cell anaemia Results from a multipleinflowtime arterial spin labelling study

Hydrogen/deuterium exchange in mass spectrometry

Published: Mar 30, 2018

Author(s): Yury Kostyukevich, Thamina Acter, Alexander Zherebker, Arif Ahmed, Sunghwan Kim, Eugene Nikolaev

Journal: Mass Spectrometry Reviews

The isotopic exchange approach is in use since the first observation of such reactions in 1933 by Lewis. This approach allows the investigation of the pathways of chemical and biochemical reactions, determination of structure, composition, and conformation of molecules. Mass spectrometry has now become one of the most important analytical tools for the monitoring of the isotopic exchange reactions. Investigation of...

Read More thumbnail image: Hydrogendeuterium exchange in mass spectrometry

Electron‐ion reaction‐based dissociation: A powerful ion activation method for the elucidation of natural product structures

Published: Mar 30, 2018

Author(s): Xiangfeng Chen, Ze Wang, Y.‐L. Elaine Wong, Ri Wu, Feng Zhang, T.‐W. Dominic Chan

Journal: Mass Spectrometry Reviews

The structural elucidation of natural products (NPs) remains a challenge due to their structurally diversities and unpredictable functionalities, motifs, and scaffolds. Tandem mass spectrometry (MS/MS) is an effective method that assists the full elucidation of complicated NP structures. Ion activation methods play a key role in determining the fragmentation pathways and the structural information obtained from...

Read More thumbnail image: Electronion reactionbased dissociation A powerful ion activation method for the elucidation of natural product structures

Molecules and elements for quantitative bioanalysis: The allure of using electrospray, MALDI, and ICP mass spectrometry side‐by‐side

Published: Mar 30, 2018

Author(s): Michael W. Linscheid

Journal: Mass Spectrometry Reviews

To understand biological processes, not only reliable identification, but quantification of constituents in biological processes play a pivotal role. This is especially true for the proteome: protein quantification must follow protein identification, since sometimes minute changes in abundance tell the real tale. To obtain quantitative data, many sophisticated strategies using electrospray and MALDI mass spectrometry...

Read More thumbnail image: Molecules and elements for quantitative bioanalysis The allure of using electrospray MALDI and ICP mass spectrometry sidebyside

Infrared and confocal Raman spectroscopy to differentiate changes in the protein secondary structure in normal and abnormal thyroid tissues

Published: Mar 30, 2018

Author(s): Claudio A. Téllez Soto, Lázaro P. Medeiros‐Neto, Laurita Santos, André B.O. Santos, Isabelle Ferreira, Priyanka Singh, Renata A. Canevari, Aírton A. Martin

Journal: Journal of Raman Spectroscopy

Abstract Thirty thyroid samples of normal and abnormal tissues were analyzed by infrared and confocal Raman Spectroscopy. We studied the Amide I (1,720–1,580 cm−1) spectral region in order to determine different components of the proteins' secondary structure in the samples. Peak positions of the Amide I bands were determined using the second derivative and Fourier self‐deconvolution of infrared and Raman spectra. We obtained...

Read More thumbnail image: Infrared and confocal Raman spectroscopy to differentiate changes in the protein secondary structure in normal and abnormal thyroid tissues
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