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All‐dielectric core/shell resonators: From plasmon‐free SERS to multimodal analysis

Published: Feb 2, 2018

Author(s): Nicolò Bontempi, Irene Vassalini, Ivano Alessandri

Journal: Journal of Raman Spectroscopy

Abstract All‐dielectric materials are emerging as a new class of substrates for enhanced Raman scattering. As ohmic losses are reduced in the absence of plasmonic metals, Raman data obtained with dielectrics are very reproducible and reliable. This mini‐review summarizes our recent work in the field of core/shell dielectric resonators designed for Raman purposes, with a special focus on SiO2/TiO2 (T‐rex) core/shell beads. These...

Read More thumbnail image: Alldielectric coreshell resonators From plasmonfree SERS to multimodal analysis

Characterization and subtraction of luminescence background signals in high‐wavenumber Raman spectra of human tissue

Published: Feb 2, 2018

Author(s): E.M. Barroso, T.C. Bakker Schut, P.J. Caspers, I.P. Santos, E.B. Wolvius, S. Koljenović, G.J. Puppels

Journal: Journal of Raman Spectroscopy

Abstract Raman spectroscopy in the high‐wavenumber spectral region (HWR) is particularly suited for fiber‐optic in vivo medical applications. The most‐used fiber‐optic materials have negligible Raman signal in the HWR. This enables the use of simple and cheap single‐fiber‐optic probes that can be fitted in endoscopes and needles. The HWR generally shows less tissue luminescence than the fingerprint region. However, the luminescence...

Read More thumbnail image: Characterization and subtraction of luminescence background signals in highwavenumber Raman spectra of human tissue

Simultaneous analysis of oral anticancer drugs for renal cell carcinoma in human plasma using liquid chromatography/electrospray ionization tandem mass spectrometry

Published: Feb 1, 2018

Author(s): Shinya Takasaki, Masaki Tanaka, Masafumi Kikuchi, Masamitsu Maekawa, Yoshihide Kawasaki, Akihiro Ito, Yoichi Arai, Hiroaki Yamaguchi, Nariyasu Mano

Journal: Biomedical Chromatography

Abstract An analytical method using high‐performance liquid chromatography/electrospray ionization tandem mass spectrometry has been developed and validated for simultaneous measurement of four tyrosine kinase inhibitors used for renal cell carcinoma and their metabolites in human plasma. Despite their similar structures, it is difficult to measure plasma levels of these compounds simultaneously using optimal MS parameters for each...

Read More thumbnail image: Simultaneous analysis of oral anticancer drugs for renal cell carcinoma in human plasma using liquid chromatographyelectrospray ionization tandem mass spectrometry

Identification of anti‐inflammatory active ingredients from Tumuxiang by ultra‐performance liquid chromatography/quadrupole time‐of‐flight‐MS E

Published: Feb 1, 2018

Author(s): Xia Gao, Yuling Ma, Zhuowei Wang, Ruibin Bia, Pei Zhang, Fangdi Hu

Journal: Biomedical Chromatography

Abstract The dried roots of Inula helenium L. (IH) and Inula racemosa Hook f. (IR) are used commonly as folk medicine as ‘tumuxiang’ (TMX). The mixing and sharing of IH and IR in clinical use is a universal phenomenon. Modern pharmacological studies confirmed that IH and IR display anti‐inflammatory activities. However, the difference in anti‐inflammatory pharmacodynamic substances between these two herbs is still unknown. In the present...

Read More thumbnail image: Identification of antiinflammatory active ingredients from Tumuxiang by ultraperformance liquid chromatographyquadrupole timeofflightMS E

Detection of monohydroxylated polycyclic aromatic hydrocarbons in urine and particulate matter using LC separations coupled with integrated SPE and fluorescence detection or coupled with high‐resolution time‐of‐flight mass spectrometry

Published: Feb 1, 2018

Author(s): Jutta Lintelmann, Xiao Wu, Evelyn Kuhn, Sebastian Ritter, Claudia Schmidt, Ralf Zimmermann

Journal: Biomedical Chromatography

Abstract A high‐performance liquid chromatographic (HPLC) method with integrated solid‐phase extraction for the determination of 1‐hydroxypyrene and 1‐, 2‐, 3‐, 4‐ and 9‐hydroxyphenanthrene in urine was developed and validated. After enzymatic treatment and centrifugation of 500 μL urine, 100 μL of the sample was directly injected into the HPLC system. Integrated solid‐phase extraction was performed on a selective, copper...

Read More thumbnail image: Detection of monohydroxylated polycyclic aromatic hydrocarbons in urine and particulate matter using LC separations coupled with integrated SPE and fluorescence detection or coupled with highresolution timeofflight mass spectrometry

Multi‐compartmental diffusion characterization of the human cervical spinal cord in vivo using the spherical mean technique

Published: Feb 1, 2018

Author(s): Samantha By, Junzhong Xu, Bailey A. Box, Francesca R. Bagnato, Seth A. Smith

Journal: NMR in Biomedicine

The purpose of this work was to evaluate the feasibility and reproducibility of the spherical mean technique (SMT), a multi‐compartmental diffusion model, in the spinal cord of healthy controls, and to assess its ability to improve spinal cord characterization in multiple sclerosis (MS) patients at 3 T. SMT was applied in the cervical spinal cord of eight controls and six relapsing‐remitting MS patients. SMT provides an elegant...

Read More thumbnail image: Multicompartmental diffusion characterization of the human cervical spinal cord in vivo using the spherical mean technique

Application of micro‐solid‐phase extraction for the on‐site extraction of heterocyclic aromatic amines in seawater

Published: Feb 1, 2018

Author(s): Chanbasha Basheer

Journal: Journal of Separation Science

Abstract An efficient on‐site extraction technique to determine carcinogenic heterocyclic aromatic amines in seawater has been reported. A micro‐solid‐phase extraction device placed inside a portable battery‐operated pump was used for the on‐site extraction of seawater samples. Before on‐site applications, parameters that influence the extraction efficiency (extraction time, type of sorbent materials, suitable desorption solvent,...

Read More thumbnail image: Application of microsolidphase extraction for the onsite extraction of heterocyclic aromatic amines in seawater

Comparison between core–shell and totally porous particle stationary phases for fast and green LC determination of five hepatitis‐C antiviral drugs

Published: Feb 1, 2018

Author(s): Adel Ehab Ibrahim, Hisham Hashem, Magda Elhenawee, Hanaa Saleh

Journal: Journal of Separation Science

Abstract The performances of core–shell 2.7 μm and fully porous sub‐2 μm particles packed in narrow diameter columns were compared under the same chromatographic conditions. The stationary phases were compared for fast separation and determination of five new antiviral drugs; daclatasvir, sofosbuvir, velpatasvir, simeprevir, and ledipasvir. The gradient elution was done using ethanol as green organic modifier, which is...

Read More thumbnail image: Comparison between coreshell and totally porous particle stationary phases for fast and green LC determination of five hepatitisC antiviral drugs

A novel ranking distance measure combining Cayley and Spearman footrule metrics

Published: Feb 1, 2018

Author(s): László Sipos, Attila Gere, József Popp, Sándor Kovács

Journal: Journal of Chemometrics

Abstract Defining the appropriate ranking distance measures among rankings is a classic area of study. The goal of our work is to identify a combination of methodologies, which is proven to be capable for the determination of a proper ranking system. In our study, we used 3 well‐established metrics: Kendall tau, Spearman footrule, and Cayley distance and a novel metric created by the combination of Cayley and Spearman footrule...

Read More thumbnail image: A novel ranking distance measure combining Cayley and Spearman footrule metrics

Ensemble learning model based on selected diverse principal component analysis models for process monitoring

Published: Feb 1, 2018

Author(s): Zhichao Li, Xuefeng Yan

Journal: Journal of Chemometrics

Abstract Principal component analysis (PCA) is extensively applied in industrial process monitoring. For optimal performance monitoring, different faults may require different principal components (PCs). However, at present, it only selects PCs of the highest variance to create a single PCA model, thereby leading to information loss and poor monitoring performance. For the solution of this problem, a method based on ensemble...

Read More thumbnail image: Ensemble learning model based on selected diverse principal component analysis models for process monitoring

Linear discriminant analysis, partial least squares discriminant analysis, and soft independent modeling of class analogy of experimental and simulated near‐infrared spectra of a cultivation medium for mammalian cells

Published: Feb 1, 2018

Author(s): Éva Szabó, Szilveszter Gergely, András Salgó

Journal: Journal of Chemometrics

Abstract Currently, the qualification and control of medium formulations are performed based on simple methods (eg, pH and osmolality measurement of medium solutions), expensive and time‐consuming cell culture tests, and the quantification of certain critical compounds by liquid chromatography. In addition to traditional medium qualification tools, relatively new spectroscopic techniques, such as fluorescence spectroscopy, nuclear...

Read More thumbnail image: Linear discriminant analysis partial least squares discriminant analysis and soft independent modeling of class analogy of experimental and simulated nearinfrared spectra of a cultivation medium for mammalian cells

Spectral clustering in eye‐movement researches

Published: Feb 1, 2018

Author(s): Attila Gere, Sándor Kovács, László Sipos

Journal: Journal of Chemometrics

Abstract Eye tracking is a widely used technology to capture the eye movements of participants completing different tasks. Several eye‐tracking parameters are measured, which later can be used to characterize the gazing pattern of the individuals. Clustering based on the path walked on by the participants may enable the researchers to create clusters based on the unconscious personality and thinking style. Common clustering methods...

Read More thumbnail image: Spectral clustering in eyemovement researches

γ‐Secretase Inhibition Induces Muscle Hypertrophy in a Notch‐Independent Mechanism

Published: Feb 1, 2018

Author(s): Ivone Rosa de Andrade, Stephany Corrêa, Marcio Fontenele, John Douglas Oliveira Teixeira, Eliana Abdelhay, Manoel Luis Costa, Claudia Mermelstein

Journal: PROTEOMICS

Abstract A wide variety of cellular processes and signaling events are regulated by the proteolytic enzyme γ‐secretase. Notch‐1 is one of the substrates of γ‐secretase and its role in the regulation of muscle differentiation has been well described. Importantly, besides Notch‐1, a number of proteins have been identified to undergo proteolysis by γ‐secretase. To date, the specific role of γ‐secretase during embryonic skeletal muscle...

Read More thumbnail image: Secretase Inhibition Induces Muscle Hypertrophy in a NotchIndependent Mechanism

Cancer Associated Fibroblasts: The Architects of Stroma Remodeling

Published: Feb 1, 2018

Author(s): Alice Santi, Fernanda G. Kugeratski, Sara Zanivan

Journal: PROTEOMICS

Abstract Fibroblasts have exceptional phenotypic plasticity and capability to secrete vast amount of soluble factors, extracellular matrix components and extracellular vesicles. While in physiological conditions this makes fibroblasts master regulators of tissue homeostasis and healing of injured tissues, in solid tumors cancer associated fibroblasts (CAFs) co‐evolve with the disease, and alter the biochemical and physical structure...

Read More thumbnail image: Cancer Associated Fibroblasts The Architects of Stroma Remodeling

A combination of dispersive liquid–liquid microextraction and surface plasmon resonance sensing of gold nanoparticles for the determination of ziram pesticide

Published: Feb 1, 2018

Author(s): Fatemeh Hashemi, Saadat Rastegarzadeh, Nahid Pourreza

Journal: Journal of Separation Science

Abstract We have developed a reliable, fast, and highly sensitive analytical method utilizing dispersive liquid–liquid microextraction and gold nanoparticles probes for ziram (zinc bis(dimethyldithiocarbamate)) determination. The method is based on the in situ formation of gold nanoparticles in carbon tetrachloride as an organic phase. It was found that the trace levels of ziram influenced the formation of gold nanoparticles,...

Read More thumbnail image: A combination of dispersive liquidliquid microextraction and surface plasmon resonance sensing of gold nanoparticles for the determination of ziram pesticide

Optimization of the surface modification process of cross‐linked polythiol‐coated chiral stationary phases synthesized by a two‐step thiol‐ene click reaction #

Published: Feb 1, 2018

Author(s): Kristina Schmitt, Michael Lämmerhofer

Journal: Journal of Separation Science

Abstract A new platform technology for the preparation of stable chiral stationary phases was successfully optimized. The chiral selector tert‐butylcarbamoylquinine was firstly covalently connected to the polymer poly(3‐mercaptopropyl)methylsiloxane by thiol‐ene click reaction. Secondly, the quinine carbamate functionalized polysiloxane conjugate was coated onto the surface of vinyl modified silica particles and cross‐linked via...

Read More thumbnail image: Optimization of the surface modification process of crosslinked polythiolcoated chiral stationary phases synthesized by a twostep thiolene click reaction

HPLC–MS/MS determination of flavonoids in Gleditsiae Spina for its quality assessment

Published: Feb 1, 2018

Author(s): Jing Li, Kun Jiang, Li‐Jun Wang, Guo Yin, Jue Wang, Yang Wang, Yi‐Bao Jin, Qing Li, Tie‐Jie Wang

Journal: Journal of Separation Science

Abstract Gleditsiae Spina, the thorn of Gleditsia sinensis Lam., has been used as an anti‐inflammatory, anti‐tumor, and anti‐bacterial traditional medicine for hundreds of years in China. This study used high‐performance liquid chromatography and tandem mass spectrometry combined with chemometric methods to allow the fast and accurate identification and quantification of the flavonoids compounds in Gleditsiae Spina, and created ...

Read More thumbnail image: HPLCMSMS determination of flavonoids in Gleditsiae Spina for its quality assessment

A convenient ultrasound‐assisted saponification for the simultaneous determination of vitamin E isomers in vegetable oil by HPLC with fluorescence detection

Published: Feb 1, 2018

Author(s): Yi Yang, Dan Lu, Shuo Yin, Danni Yang, Yaling Chen, Yongxin Li, Chengjun Sun

Journal: Journal of Separation Science

Abstract An efficient ultrasound‐assisted saponification was developed for simultaneous determination of vitamin E isomers in vegetable oil by high‐performance liquid chromatography with fluorescence detection. The samples were saponified ultrasonically with potassium hydroxide solution for only 7 min, then the analytes were extracted with ether. Vitamin E isomers were separated on a C18 column at 25°C with a mobile phase of...

Read More thumbnail image: A convenient ultrasoundassisted saponification for the simultaneous determination of vitamin E isomers in vegetable oil by HPLC with fluorescence detection

Flotation/ultrasound‐assisted microextraction followed by HPLC for determination of fat‐soluble vitamins in multivitamin pharmaceutical preparations

Published: Feb 1, 2018

Author(s): Parvin Shahdousti, Mohammad Aghamohammadi

Journal: Journal of Separation Science

Abstract Dissolved carbon dioxide flotation–emulsification microextraction technique coupled with high‐performance liquid chromatography was developed for separation and determination of fat‐soluble vitamins (A, D3, E, and K3) in multivitamin pharmaceutical preparations. Dissolved carbon dioxide flotation was used to break up the emulsion of extraction solvent in water and to collect the extraction solvent on the surface of aqueous sample in...

Read More thumbnail image: Flotationultrasoundassisted microextraction followed by HPLC for determination of fatsoluble vitamins in multivitamin pharmaceutical preparations

A novel spinel coating on cobalt‐based Superalloy GH605 via an in‐situ oxidation approach

Published: Feb 1, 2018

Author(s): Kai Zhang, Jinglei Liu, Binbin Bao, Hong Xu

Journal: Surface and Interface Analysis

Cr‐Mn‐O spinel coating was prepared on the surface of cobalt‐based superalloy GH605 via an in‐situ oxidation method in H2O‐H2 environment. The composition, morphology, and chemical value state of the oxide spinel coatings were investigated by SEM, EDS, XRD, Raman spectra, and XPS. It indicated that the morphology of coating varied with oxidation temperature, and granular surface appeared when oxidation temperature increased to 1100°C. The formed...

Read More thumbnail image: A novel spinel coating on cobaltbased Superalloy GH605 via an insitu oxidation approach
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