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An air‐assisted flow‐gating interface for capillary electrophoresis

Published: Nov 22, 2018

Author(s): František Opekar, Petr Tůma

Journal: ELECTROPHORESIS

Abstract A new kind of flow gating interface (FGI) has been designed for online connection of CE with flow‐through analytical techniques. The sample is injected into the separation capillary from a space from which the BGE was forced out by compressed air. A drop of sample solution with a volume of 75 nL is formed between the outlet of the delivery capillary supplying the solution from the flow‐through apparatus and the entrance to...

Read More thumbnail image: An airassisted flowgating interface for capillary electrophoresis

Rapid separation of post‐blast explosive residues on glass electrophoresis microchips

Published: Nov 22, 2018

Author(s): Kemilly M. P. Pinheiro, Roger C. Moreira, Kariolanda C. A. Rezende, Márcio Talhavini, Lucio P. L. Logrado, José A. F. Baio, Marcos R. V. Lanza, Wendell K. T. Coltro

Journal: ELECTROPHORESIS

Abstract This study describes the development of an analytical methodology based on the use of microchip electrophoresis (ME) devices integrated with capacitively coupled contactless conductivity detection (C4D) for the separation and detection of inorganic anions in post‐blast explosive residues. The best separation condition was achieved using a running buffer composed of 35 mmol/L lactic acid, 10 mmol/L histidine and...

Read More thumbnail image: Rapid separation of postblast explosive residues on glass electrophoresis microchips

Metabolite profiling of l ‐isocorypalmine in rat urine, plasma, and feces after oral administration using high performance liquid chromatography coupled to Fourier transform ion cyclotron resonance mass spectrometry

Published: Nov 22, 2018

Author(s): Yiran Li, Teng Zhang, Jiaxin Huai, Congcong Cheng, Linlin Xie, Siqi Wang, Ronghua Dai

Journal: Journal of Separation Science

Abstract l‐Isocorypalmine, an active alkaloid compound isolated from Rhizoma Corydalis yanhusuo, has been reported to possess biological activity for treating cocaine use disorder. A high‐performance liquid chromatography coupled to Fourier transform ion cyclotron resonance mass spectrometry method was established for identification of the metabolites of l‐isocorypalmine in urine, plasma and feces samples of rats after a single intragastric...

Read More thumbnail image: Metabolite profiling of l isocorypalmine in rat urine plasma and feces after oral administration using high performance liquid chromatography coupled to Fourier transform ion cyclotron resonance mass spectrometry

PLS multivariate analysis applied to corrosion studies on reinforced concrete

Published: Nov 22, 2018

Author(s): Pablo Monzón, José Enrique Ramón, José Manuel Gandía‐Romero, Manuel Valcuende, Juan Soto, Daniel Palací‐López

Journal: Journal of Chemometrics

Abstract There are few techniques available to calculate the corrosion rate (icorr) of reinforcing steel in concrete structures. This is due not only to a lack of instrumentation but also because it is necessary to take into account that polarization can irreversibly modify the metal surface and can affect the results or the future state of the metal. This is the reason some researchers prefer to test reinforcing steel with reversible...

Read More thumbnail image: PLS multivariate analysis applied to corrosion studies on reinforced concrete

Development of a headspace solid‐phase microextraction–surface‐enhanced Raman scattering approach to detect volatile pesticides

Published: Nov 22, 2018

Author(s): Chunrong Wang, Zhiyun Zhang, Lili He

Journal: Journal of Raman Spectroscopy

Abstract By coupling headspace solid‐phase microextraction (HS‐SPME) with surface‐enhanced Raman scattering (SERS), a facile and rapid method was developed for the detection of organophosphorus insecticides (phorate and isocarbophos) and organic sulfur bactericide (ferbam) in the vapour phase. Two types of SPME fibres based on stainless steel wires coated with gold (Au) nanoparticles were prepared. The fibre (Fibre II) prepared by...

Read More thumbnail image: Development of a headspace solidphase microextractionsurfaceenhanced Raman scattering approach to detect volatile pesticides

Raman spectra analysis of ZrO 2 thermally grown on Zircaloy substrates irradiated with heavy ion: Effects of oxygen isotopic substitution

Published: Nov 22, 2018

Author(s): Clément Ciszak, Michel Mermoux, Gaëlle Gutierrez, Frédéric Leprêtre, Christian Duriez, Ioana Popa, Laurent Fayette, Sébastien Chevalier

Journal: Journal of Raman Spectroscopy

Abstract Recently, unusual Raman signals were observed in different works conducted on thin zirconia layers grown on zirconium alloys simulating in‐reactor materials after high fluence ion irradiation or for samples cut from fuel rods irradiated in nuclear plants. As such, these spectra clearly do not correspond to any known spectrum of a pure standard zirconia phase. Therefore, the analysis conducted in this paper aims to provide a...

Read More thumbnail image: Raman spectra analysis of ZrO 2 thermally grown on Zircaloy substrates irradiated with heavy ion Effects of oxygen isotopic substitution

Machine learning algorithms applied to R aman spectra for the identification of variscite originating from the mining complex of G avà

Published: Nov 22, 2018

Author(s): José Francisco Díez‐Pastor, Susana Esther Jorge‐Villar, Álvar Arnaiz‐González, César Ignacio García‐Osorio, Yael Díaz‐Acha, Marc Campeny, Josep Bosch, Joan Carles Melgarejo

Journal: Journal of Raman Spectroscopy

Abstract Variscite is an aluminium phosphate mineral widely used as a gemstone in antiquity. Knowledge of the ancient trade in variscite has important implications on the historical appreciation of the commercial and migratory movements of human population. The mining complex of Gavà, which dates from the Neolithic, is one of the oldest underground mine sites in Europe, from where variscite was extracted from several mines and at...

Read More thumbnail image: Machine learning algorithms applied to R aman spectra for the identification of variscite originating from the mining complex of G ava

Determination of tubuloside B by LC–MS/MS and its application to a pharmacokinetic study in rats

Published: Nov 22, 2018

Author(s): Shengbao Yang, Ruiying Qu, Peilu Sun, Shan Xiong, Siyi Yan, Zhipeng Deng

Journal: Biomedical Chromatography

Read More thumbnail image: Determination of tubuloside B by LCMSMS and its application to a pharmacokinetic study in rats

Validated LC–MS/MS method for the quantification of sciadopitysin in rat plasma and its application to pharmacokinetic and bioavailability studies in vivo

Published: Nov 22, 2018

Author(s): Shengbao Yang, Ruiying Qu, Zhe Zhu, Wei Li, Chengliang Zhao, Liantai Li

Journal: Biomedical Chromatography

Read More thumbnail image: Validated LCMSMS method for the quantification of sciadopitysin in rat plasma and its application to pharmacokinetic and bioavailability studies in vivo

Rapid quantitative analysis of etoricoxib in human plasma by UPLC‐MS/MS and application to a pharmacokinetic study in Chinese healthy volunteers

Published: Nov 22, 2018

Author(s): Xiaoran Zhang, Nan Guo, Wei Ji, Qing Wen

Journal: Biomedical Chromatography

Abstract A selective and sensitive liquid chromatography–tandem mass spectrometry method was developed for simultaneous determination of etoricoxib in human plasma. Chromatography was performed on an Acquity UPLC HSS T3 column (1.8 μm, 50 × 2.1 mm), with a flow rate of 0.600 mL/min, using a gradient elution with acetonitrile and water which contained 2 mm ammonium acetate as the mobile phase. Detection was carried out on Triple QuadTM 5500 mass...

Read More thumbnail image: Rapid quantitative analysis of etoricoxib in human plasma by UPLCMSMS and application to a pharmacokinetic study in Chinese healthy volunteers

Pharmacokinetics and tissue distribution of oroxin B in rats using a validated LC–MS/MS assay

Published: Nov 21, 2018

Author(s): Kai Niu, Huiyu Yan, Chunjie Guo, Sixi Zhang, Wei Zhu, Shiyong Teng

Journal: Biomedical Chromatography

Abstract A highly sensitive LC–MS/MS method was developed to measure oroxin B in rat plasma and tissue homogenates. The analyte and IS were isolated from biological matrices by a simple protein precipitation followed by centrifugation. Detection was conducted by electrospray negative‐ionization mass spectrometry in selected‐reaction monitoring mode. The assay was linear in the concentration range 4.52–904 ng/mL with intra‐ and...

Read More thumbnail image: Pharmacokinetics and tissue distribution of oroxin B in rats using a validated LCMSMS assay

Target separation of flavonoids from Saxifraga tangutica using two‐dimensional hydrophilic interaction chromatography/reversed‐phase liquid chromatography

Published: Nov 21, 2018

Author(s): Jun Dang, Li Zhang, Qilan Wang, Lijuan Mei, Huilan Yue, Zenggen Liu, Yun Shao, Qingbo Gao, Yanduo Tao

Journal: Journal of Separation Science

Abstract An orthogonally (80.3%) preparative two‐dimensional hydrophilic interaction chromatography/reversed‐phase liquid chromatography method has been established for the isolation and purification of flavonoids from Saxifraga tangutica. Initially, flavonoids were enriched by means of a middle‐pressure chromatographic tower (containing middle chromatogram isolated gel). In the first dimension, a XION preparative column was used to separate...

Read More thumbnail image: Target separation of flavonoids from Saxifraga tangutica using twodimensional hydrophilic interaction chromatographyreversedphase liquid chromatography

Optimization of solid‐phase extraction of parabens and benzophenones in water samples using a combination of Plakett‐Burman and Box‐Behnken designs

Published: Nov 21, 2018

Author(s): Carmin A. Chávez‐Moreno, Laura Hinojosa‐Reyes, Edgar J. Ruiz‐Ruiz, Aracely Hernández‐Ramírez, Jorge L. Guzmán‐Mar

Journal: Journal of Separation Science

Abstract An automated method for the analysis of methylparaben, propylparaben, benzophenone‐3, and benzophenone‐4 in water effluents via on‐line solid‐phase extraction coupled with high‐performance liquid chromatography/ultraviolet detection was proposed. The preconcentration parameters were studied using Plackett‐Burman and Box‐Behnken experimental designs using a C18 sorbent material. The results demonstrated that the eluent...

Read More thumbnail image: Optimization of solidphase extraction of parabens and benzophenones in water samples using a combination of PlakettBurman and BoxBehnken designs

Assessment of quality consistency in traditional Chinese medicine using multi‐wavelength fusion profiling by integrated quantitative fingerprint method: Niuhuang Jiedu pill as an example

Published: Nov 21, 2018

Author(s): Jing Zhang, Guoxiang Sun

Journal: Journal of Separation Science

Abstract Under the wave of the revival of traditional Chinese medicine, there is a quite imperative duty to study an integrated and comprehensive method of fingerprint data processing and analysis on the quality consistency of traditional Chinese medicine. So, we proposed six parameters from two aspects (qualitative and quantitative), three levels (biased to strong peaks, biased to weak peaks, no obvious bias), to comprehensively...

Read More thumbnail image: Assessment of quality consistency in traditional Chinese medicine using multiwavelength fusion profiling by integrated quantitative fingerprint method Niuhuang Jiedu pill as an example

Mapping tissue water T 1 in the liver using the MOLLI T 1 method in the presence of fat, iron and B 0 inhomogeneity

Published: Nov 21, 2018

Author(s): Ferenc E. Mozes, Elizabeth M. Tunnicliffe, Ahmad Moolla, Thomas Marjot, Christina K. Levick, Michael Pavlides, Matthew D. Robson

Journal: NMR in Biomedicine

Modified Look‐Locker inversion recovery (MOLLI) T1 mapping sequences can be useful in cardiac and liver tissue characterization, but determining underlying water T1 is confounded by iron, fat and frequency offsets. This article proposes an algorithm that provides an independent water MOLLI T1 (referred to as on‐resonance water T1) that would have been measured if a subject had no fat and normal iron, and imaging had been done on resonance. Fifteen NiCl2‐doped...

Read More thumbnail image: Mapping tissue water T 1 in the liver using the MOLLI T 1 method in the presence of fat iron and B 0 inhomogeneity

Detection of bemitil and its metabolite in urine by means of LC–MS/MS in view of doping control analysis

Published: Nov 20, 2018

Author(s): Dorota Kwiatkowska, Katarzyna Kowalczyk, Krzysztof Grucza, Mirosław Szutowski, Ewa Bulska, Mariola Wicka

Journal: Drug Testing and Analysis

Abstract 2‐(Ethylthio) benzimidazole is an active ingredient of Antihot, a dietary supplement sold in Ukraine. The substance, available also under names of Bemitil, Metaprot, and Bemaktor, was developed in the USSR in 1970s, and after tests on Soviet cosmonauts and soldiers, several studies on its influence on athletes' performances were conducted. The research showed that bemitil is a synthetic adaptogen which is capable to...

Read More thumbnail image: Detection of bemitil and its metabolite in urine by means of LCMSMS in view of doping control analysis

Sulfate metabolites improve retrospectivity after oral testosterone administration

Published: Nov 20, 2018

Author(s): Argitxu Esquivel, Élida Alechaga, Nuria Monfort, Rosa Ventura

Journal: Drug Testing and Analysis

Abstract The detection of testosterone (T) misuse is performed using the steroid profile that includes concentrations of T and related metabolites excreted free and glucuronoconjugated, and the ratios between them. In this work, the usefulness of 14 endogenous steroid sulfates to improve the detection capabilities of oral T administration has been evaluated. Quantitation of the sulfate metabolites was performed using solid‐phase...

Read More thumbnail image: Sulfate metabolites improve retrospectivity after oral testosterone administration

Metabolomics‐based parallel discovery of xenobiotics and induced endogenous metabolic dysregulation in clinical toxicology

Published: Nov 20, 2018

Author(s): Chang Chen, Ziquan Fan, Hui Xu, Xiaojie Tan, Mingshe Zhu

Journal: Biomedical Chromatography

Abstract Intoxication by xenobiotics triggers the perturbation of metabolic fingerprints in biofluids, including the accumulation of xenobiotic compounds and the dysregulation of endogenous metabolites. In this work, an untargeted metabolomics workflow was developed to simultaneously profile both xenobiotic and endogenous metabolites for the identification of the xenobiotic origin and an in‐depth understanding of the intoxication...

Read More thumbnail image: Metabolomicsbased parallel discovery of xenobiotics and induced endogenous metabolic dysregulation in clinical toxicology

Comparative metabolism of the eight main bioactive ingredients of gegen qinlian decoction by the intestinal flora of diarrhoeal and healthy piglets

Published: Nov 20, 2018

Author(s): Chang‐Shun Liu, Xiao Liang, Xiao‐Han Wei, Fei‐Long Chen, Qing‐Fa Tang, Xiao‐Mei Tan

Journal: Biomedical Chromatography

Abstract Diarrhoeal diseases alter the composition of intestinal flora, thereby affecting the efficacy of herbal medicinal formulations. Gegen Qinlian decoction (GQD), a Chinese traditional herbal formulation, is widely used to treat infectious diarrhoea. However, little is known about the microbial disposition of GQD in the diarrhoeal state. In this study, the comparative metabolism of components of GQD by diarrhoeal and normal...

Read More thumbnail image: Comparative metabolism of the eight main bioactive ingredients of gegen qinlian decoction by the intestinal flora of diarrhoeal and healthy piglets

Isolation and determination of saponin hydrolysis products from Medicago sativa using supercritical fluid extraction, solid‐phase extraction and liquid chromatography with evaporative light scattering detection

Published: Nov 20, 2018

Author(s): Anna Kiełbasa, Aneta Krakowska, Katarzyna Rafińska, Bogusław Buszewski

Journal: Journal of Separation Science

Abstract Saponins are widespread secondary metabolites with various beneficial properties: fungicidal, antibacterial, antiviral, and anticancer. Alfalfa saponin molecules contain mainly: medicagenic acid, hederagenin, bayogenin, and soyasapogenol B. Structural diversity of saponins makes their determination in Medicago sativa extracts very difficult. The most popular determination technique is high‐performance liquid chromatography applied...

Read More thumbnail image: Isolation and determination of saponin hydrolysis products from Medicago sativa using supercritical fluid extraction solidphase extraction and liquid chromatography with evaporative light scattering detection
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