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Simultaneous derivatization and air‐assisted liquid–liquid microextraction of some parabens in personal care products and their determination by GC with flame ionization detection

Published: Sep 25, 2013

Author(s): Mir Ali Farajzadeh, Elnaz Marzi Khosrowshahi, Parisa Khorram

Journal: Journal of Separation Science

A simultaneous derivatization/air‐assisted liquid–liquid microextraction technique has been developed for the sample pretreatment of some parabens in aqueous samples. The analytes were derivatized and extracted simultaneously by a fast reaction/extraction with butylchloroformate (derivatization agent/extraction solvent) from the aqueous samples and then analyzed by GC with flame ionization detection. The effect of catalyst type and...

Read More thumbnail image: Simultaneous derivatization and airassisted liquidliquid microextraction of some parabens in personal care products and their determination by GC with flame ionization detection

Electrolyte system strategies for anionic isotachophoresis with electrospray‐ionization mass‐spectrometric detection. 1. Regular isotachophoresis and free‐acid isotachophoresis.

Published: Sep 25, 2013

Author(s): Zdena Malá, Petr Gebauer, Petr Boček

Journal: ELECTROPHORESIS

The subject of this work is the definition of a simple model based on general ITP theory that allows describing and predicting the behavior of ITP systems compatible with ESI‐MS detection. The model is exemplified by anionic ITP of weak acids that represent an interesting potential application field of ITP‐ESI‐MS. Suitable ESI‐compatible electrolyte systems of very simple composition are proposed including a special free‐acid ITP...

Read More thumbnail image: Electrolyte system strategies for anionic isotachophoresis with electrosprayionization massspectrometric detection_ 1_ Regular isotachophoresis and freeacid isotachophoresis_

Differentiation of strains from the Bacillus cereus group by RFLPPFGE genomic fingerprinting

Published: Sep 25, 2013

Author(s): Anna Otlewska, Elzbieta Oltuszak‐Walczak, Piotr Walczak

Journal: ELECTROPHORESIS

Bacillus mycoides, Bacillus pseudomycoides, Bacillus weihenstephanensis, Bacillus anthracis, Bacillus thuringiensis, and Bacillus cereus belong to the B. cereus group. The last three species are characterized by different phenotype features and pathogenicity spectrum, but it has been shown that these species are genetically closely related. The macrorestriction analysis of the genomic DNA with the NotI enzyme was used to generate polymorphism of restriction...

Read More thumbnail image: Differentiation of strains from the Bacillus cereus group by RFLP  PFGE genomic fingerprinting

Effects of fat on MR‐measured metabolite signal strengths: implications for in vivo MRS studies of the human brain

Published: Sep 24, 2013

Author(s): Anderson Mon, Christoph Abé, Timothy C. Durazzo, Dieter J. Meyerhoff

Journal: NMR in Biomedicine

Recent MRS studies have indicated that a higher body mass index (BMI) is associated with lower brain metabolite levels. Generally, individuals with higher BMIs have more body fat deposits than individuals with normal BMIs. This single‐voxel spectroscopy (SVS) study investigated possible effects of fat on MR‐measured metabolite signal areas, which may at least partly explain the observed associations of BMI with MR‐measured brain...

Read More thumbnail image: Effects of fat on MRmeasured metabolite signal strengths implications for in vivo MRS studies of the human brain

Hyperpolarized 13 C NMR studies of glucose metabolism in living breast cancer cell cultures

Published: Sep 24, 2013

Author(s): T. Harris, H. Degani, L. Frydman

Journal: NMR in Biomedicine

The recent development of dissolution dynamic nuclear polarization (DNP) gives NMR the sensitivity to follow metabolic processes in living systems with high temporal resolution. In this article, we apply dissolution DNP to study the metabolism of hyperpolarized U‐13C,2H7‐glucose in living, perfused human breast cancer cells. Spectrally selective pulses were used to maximize the signal of the main product, lactate, whilst preserving the...

Read More thumbnail image: Hyperpolarized 13 C NMR studies of glucose metabolism in living breast cancer cell cultures

Simultaneous isolation of seven compounds from Glehnia littoralis roots by off‐line overpressured layer chromatography guided by a TLC antioxidant autographic assay

Published: Sep 24, 2013

Author(s): Xing Su, Xiangkun Li, Hongxun Tao, Jinge Zhou, Tao Wu, Guixin Chou, Zhihong Cheng

Journal: Journal of Separation Science

A combinative method using overpressured layer chromatography (OPLC) and TLC bioautography against O2•− was developed to separate antioxidants from Glehnia littoralis roots. Through target‐directed isolation by the TLC bioautographic method, seven compounds including five antioxidants were rapidly isolated by OPLC and identified as 1‐linoloyl‐3‐palmitoylglycerol, facarindiol, panaxynol, isoimperatorin, β‐sitosterol, scopoletin, and umbelliferone from...

Read More thumbnail image: Simultaneous isolation of seven compounds from Glehnia littoralis roots by offline overpressured layer chromatography guided by a TLC antioxidant autographic assay

Identification of annexin II as a novel secretory biomarker for breast cancer

Published: Sep 24, 2013

Author(s): You Rim Jeon, Sun Young Kim, Eun Jeong Lee, Yong Nyun Kim, Dong‐Young Noh, So Yeon Park, Aree Moon

Journal: PROTEOMICS

Early prediction of metastatic breast cancer is important for improvement of prognosis and survival rate. The present study aimed to identify secreted protein biomarkers for detection of invasive breast cancer. To this end, we performed a comparative proteomic analysis by a combination of 2DE and MALDI‐TOF MS analysis of conditioned media from invasive H‐Ras MCF10A human breast epithelial cells and noninvasive MCF10A and N‐Ras MCF10A...

Read More thumbnail image: Identification of annexin II as a novel secretory biomarker for breast cancer

Development and validation of a fast and simple multi‐analyte procedure for quantification of 40 drugs relevant to emergency toxicology using GC‐MS and one‐point calibration

Published: Sep 24, 2013

Author(s): Golo M. J. Meyer, Armin A. Weber, Hans H. Maurer

Journal: Drug Testing and Analysis

Diagnosis and prognosis of poisonings should be confirmed by comprehensive screening and reliable quantification of xenobiotics, for example by gas chromatography–mass spectrometry (GC‐MS) or liquid chromatography‐mass spectrometry (LC‐MS). The turnaround time should be short enough to have an impact on clinical decisions. In emergency toxicology, quantification using full‐scan acquisition is preferable because this allows screening and...

Read More thumbnail image: Development and validation of a fast and simple multianalyte procedure for quantification of 40 drugs relevant to emergency toxicology using GCMS and onepoint calibration

A population study of urine glycerol concentrations in elite athletes competing in North America

Published: Sep 24, 2013

Author(s): Brian N. Kelly, Myke Madsen, Ken Sharpe, Vinod Nair, Daniel Eichner

Journal: Drug Testing and Analysis

Glycerol is an endogenous substance that is on the World Anti‐Doping Agency's list of prohibited threshold substances due to its potential use as a plasma volume expansion agent. The WADA has set the threshold for urine glycerol, including measurement uncertainty, at 1.3 mg/mL. Glycerol in circulation largely comes from metabolism of triglycerides in order to meet energy requirements and when the renal threshold is eclipsed, glycerol is...

Read More thumbnail image: A population study of urine glycerol concentrations in elite athletes competing in North America

Non‐enzymatic glycation and glycoxidation protein products in foods and diseases: An interconnected, complex scenario fully open to innovative proteomic studies

Published: Sep 24, 2013

Author(s): Simona Arena, Anna Maria Salzano, Giovanni Renzone, Chiara D'Ambrosio, Andrea Scaloni

Journal: Mass Spectrometry Reviews

Abstract The Maillard reaction includes a complex network of processes affecting food and biopharmaceutical products; it also occurs in living organisms and has been strictly related to cell aging, to the pathogenesis of several (chronic) diseases, such as diabetes, uremia, cataract, liver cirrhosis and various neurodegenerative pathologies, as well as to peritoneal dialysis treatment. Dozens of compounds are...

Read More thumbnail image: Nonenzymatic glycation and glycoxidation protein products in foods and diseases An interconnected complex scenario fully open to innovative proteomic studies

Choice of optimal conditions for X‐ray fluorescence analysis of milk products with varying fat content

Published: Sep 23, 2013

Author(s): A. N. Smagunova, G. V. Pashkova

Journal: X-Ray Spectrometry

The design of experiments was used to study sources of errors in the sample preparation and to choose optimal conditions for X‐ray fluorescence (XRF) analysis of milk products of varying fat content. The measurements were performed using the conventional wavelength‐dispersive XRF (WDXRF) and the total reflection XRF (TXRF) techniques. For WDXRF, the dried milk samples were pelletized, and the mathematical models were constructed, which...

Read More thumbnail image: Choice of optimal conditions for Xray fluorescence analysis of milk products with varying fat content

Ultra‐high‐performance liquid chromatography–tandem mass spectrometry for pharmacokinetics of bakuchiol in rats

Published: Sep 23, 2013

Author(s): Shuang‐Qing Zhang, Yu‐Ming Fan

Journal: Biomedical Chromatography

ABSTRACT Psoralea Corylifolia L. is a traditional Chinese medicine with many beneficial effects in medical therapies. Bakuchiol was the main active ingredient of Psoralea Corylifolia L., used for the treatment of various diseases and also as a natural food additive. A specific and reliable ultra‐high performance liquid chromatography–tandem mass spectrometry has been developed and fully validated for the quantification of bakuchiol ...

Read More thumbnail image: Ultrahighperformance liquid chromatographytandem mass spectrometry for pharmacokinetics of bakuchiol in rats

5‐(2‐Aminopropyl)indole (5‐IT): a psychoactive substance used for recreational purposes is an inhibitor of human monoamine oxidase (MAO)

Published: Sep 20, 2013

Author(s): Tomás Herraiz, Simon D. Brandt

Journal: Drug Testing and Analysis

5‐(2‐Aminopropyl)indole (5‐IT) is a psychoactive compound that has recently been associated with several fatal and non‐fatal intoxications in a number of European countries. There are indications that acute effects may include symptoms of monoaminergic (e.g. serotonin) toxicity and one mechanism involved in the increase of serotonin levels includes the inhibition of monoamine oxidase. This study investigated the effect of 5‐IT on human...

Read More thumbnail image: 52Aminopropylindole 5IT a psychoactive substance used for recreational purposes is an inhibitor of human monoamine oxidase MAO

Enantiomeric separations of illicit drugs and controlled substances using cyclofructan‐based (LARIHC) and cyclobond I 2000 RSP HPLC chiral stationary phases

Published: Sep 20, 2013

Author(s): Nilusha L.T. Padivitage, Edra Dodbiba, Zachary S. Breitbach, Daniel W. Armstrong

Journal: Drug Testing and Analysis

Recently a novel class of chiral stationary phases (CSPs) based on cyclofructan (CF) has been developed. Cyclofructans are cyclic oligosaccharides that possess a crown ether core and pendent fructofuranose moieties. Herein, we evaluate the applicability of these novel CSPs for the enantiomeric separation of chiral illicit drugs and controlled substances directly without any derivatization. A set of 20 racemic compounds were used to...

Read More thumbnail image: Enantiomeric separations of illicit drugs and controlled substances using cyclofructanbased LARIHC and cyclobond I 2000 RSP HPLC chiral stationary phases

Altitude exposure in sports: the Athlete Biological Passport standpoint

Published: Sep 20, 2013

Author(s): Fabian Sanchis‐Gomar, Helios Pareja Galeano, Thomas Brioche, Vladimir Martinez‐Bello, Giuseppe Lippi

Journal: Drug Testing and Analysis

The Athlete Biological Passport (ABP) is principally founded on monitoring an athlete's biological variables over time, to identify abnormal biases on a longitudinal basis. Several factors are known to influence the results of these markers. However, the manner in which the altitude factor is taken into account still needs to be standardized. Causal relationships between haematological variables should be correctly integrated into ABP...

Read More thumbnail image: Altitude exposure in sports the Athlete Biological Passport standpoint

Noninvasive monitoring of photocatalytic degradation of X‐ray contrast media using Raman spectrometry

Published: Sep 20, 2013

Author(s): Sabina Salkic, Logan H. Eckler, Matthew J. Nee

Journal: Journal of Raman Spectroscopy

The photocatalytic degradation of the X‐ray contrast agents iohexol and diatrizoate are monitored by in situ Raman spectrometry measurements in aqueous solution with a TiO2 photocatalyst. Spectral features and changes are interpreted with the use of density functional theory calculations. While we observe similar results to those published previously, significant changes seen in the Raman spectrum allow us to better identify the mechanisms without...

Read More thumbnail image: Noninvasive monitoring of photocatalytic degradation of Xray contrast media using Raman spectrometry

Preparation and evaluation of a novel molecularly imprinted SPE monolithic capillary column for the determination of auramine O in shrimp

Published: Sep 19, 2013

Author(s): Jiangmei Li, Haiyun Zhai, Zuanguang Chen, Qing Zhou, Zhenping Liu, Zihao Su

Journal: Journal of Separation Science

A novel method combining molecular imprinting and SPE was developed in a capillary column for the determination of auramine O in shrimp. The capillary monolithic column was prepared by UV‐initiated in situ polymerization, using auramine O as template and methacrylic acid and ethylene dimethacrylate as functional monomer and cross‐linker, respectively. The properties of the prepared capillary monolithic column were investigated under the optimized...

Read More thumbnail image: Preparation and evaluation of a novel molecularly imprinted SPE monolithic capillary column for the determination of auramine O in shrimp

Nanogaps in 2D Ag‐nanocap arrays for surface‐enhanced Raman scattering

Published: Sep 19, 2013

Author(s): Yongjun Zhang, Wenting Gao, Shuo Yang, Shanshan Liu, Xiaoyu Zhao, Ming Gao, Yaxin Wang, Jinghai Yang

Journal: Journal of Raman Spectroscopy

The surface‐enhanced Raman scattering substrate of Ag–Ag nanocap arrays are prepared by depositing Ag film onto two‐dimensional (2D) polystyrene colloidal nanosphere templates. When the original colloidal arrays are used as the substrate for Ag deposition, surface‐enhanced Raman scattering (SERS) enhancements show the strong size‐dependence behaviours. When O2‐plasma etched 2D polystyrene templates are used as the substrate for Ag deposition to form...

Read More thumbnail image: Nanogaps in 2D Agnanocap arrays for surfaceenhanced Raman scattering

Synthesis of uniform poly(d,l‐lactide) and poly(d,l‐lactide‐ co ‐glycolide) microspheres using a microfluidic chip for comparison

Published: Sep 19, 2013

Author(s): Chih‐Hui Yang, Keng‐Shiang Huang, Alexandru Mihai Grumezescu, Chih‐Yu Wang, Shian‐Chiuan Tzeng, Szu‐Yu Chen, Yu‐Hsin Lin, Yung‐Sheng Lin

Journal: ELECTROPHORESIS

Applications of poly(l‐lactide) (PLA) and poly(d,l‐lactide‐co‐glycolide) (PLGA) microspheres are widely used in the biomedical and pharmaceutical fields. The effects of PLA/PLGA on microsphere properties when using conventional particulate preparation methods are not easily defined due to the uncontrollable particle size and size distribution. This study was aimed to synthesize uniform PLA and PLGA microspheres using a phenol formaldehyde ...

Read More thumbnail image: Synthesis of uniform polydllactide and polydllactide co glycolide microspheres using a microfluidic chip for comparison

Multiplex genotyping assays for fine‐resolution subtyping of the major human Y ‐chromosome haplogroups E , G , I , J , and R in anthropological, genealogical, and forensic investigations

Published: Sep 19, 2013

Author(s): Mannis Oven, Kimberley Toscani, Nathalie Tempel, Arwin Ralf, Manfred Kayser

Journal: ELECTROPHORESIS

Inherited DNA polymorphisms located within the nonrecombing portion of the human Y chromosome provide a powerful means of tracking the patrilineal ancestry of male individuals. Recently, we introduced an efficient genotyping method for the detection of the basal Y‐chromosome haplogroups A to T, as well as an additional method for the dissection of haplogroup O into its sublineages. To further extend the use of the Y chromosome as an...

Read More thumbnail image: Multiplex genotyping assays for fineresolution subtyping of the major human Y chromosome haplogroups E  G  I  J  and R in anthropological genealogical and forensic investigations
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