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An HPLC‐UV method for the simultaneous quantification of curcumin and its metabolites in plasma and lung tissue: Potential for preclinical applications

Published: May 27, 2018

Author(s): Jagdish Mahale, Lynne M. Howells, Rajinder Singh, Robert G. Britton, Hong Cai, Karen Brown

Journal: Biomedical Chromatography

Abstract Curcumin, derived from turmeric, has been extensively investigated for its broad spectrum of biological activities. Previously reported HPLC‐UV methods have focussed on analysis of the parent compound. Here, a sensitive HPLC‐UV method was developed and partially validated, then used for the simultaneous determination of curcumin and its glucuronide and sulfate metabolites in plasma and lung tissue from mice. The assay was...

Read More thumbnail image: An HPLCUV method for the simultaneous quantification of curcumin and its metabolites in plasma and lung tissue Potential for preclinical applications

MA‐XRF study of 15th–17th century icons from the collection of the National Museum in Krakow, Poland

Published: May 27, 2018

Author(s): Małgorzata Walczak, Dominika Tarsińska‐Petruk, Michał Płotek, Maria Goryl, Mirosław P. Kruk

Journal: X-Ray Spectrometry

In 2015, the National Museum in Krakow, Poland, started a grant from the National Programme for the Development of Humanities, its goal to investigate an important collection of old Orthodox painting, including more than 50 15th to 17th century icons originating from the territory of the historical Orthodox Diocese of Przemyśl within the borders of the Polish Kingdom. The aim of researching the iconography,...

Read More thumbnail image: MAXRF study of 15th17th century icons from the collection of the National Museum in Krakow Poland

A liquid chromatography–tandem mass spectrometry method for the determination of cocaine and metabolites in blood and in dried blood spots collected from postmortem samples and evaluation of the stability over a 3‐month period

Published: May 25, 2018

Author(s): Matteo Moretti, Silvia Damiana Visonà, Francesca Freni, Ilaria Tomaciello, Claudia Vignali, Angelo Groppi, Luca Tajana, Antonio Marco Maria Osculati, Luca Morini

Journal: Drug Testing and Analysis

Abstract The aims of this study were (1) to identify and quantify cocaine (COC), benzoylecgonine (BE), ecgonine methyl ester (EME), and cocaethylene (CE) in DBS; (2) to compare dried blood spots (DBSs) analytical results with the routine blood analyses; (3) to monitor analytes stability on DBS within a 3‐month period. Eighty‐five μL of blood from postmortem cases were put on a card for DBS analysis and kept in the dark, at room...

Read More thumbnail image: A liquid chromatographytandem mass spectrometry method for the determination of cocaine and metabolites in blood and in dried blood spots collected from postmortem samples and evaluation of the stability over a 3month period

A sensitive, high‐throughput, and ecofriendly method for the determination of lumefantrine, artemether, and its active metabolite dihydroartemisinin by supercritical fluid chromatography and tandem mass spectrometry

Published: May 25, 2018

Author(s): Yinxian Yang, Hailing Gao, Shanshan Hou, Ruijuan Su, Hongzhuo Liu, Jin Sun

Journal: Journal of Separation Science

Abstract A quick and sensitive supercritical fluid chromatography with tandem mass spectrometry method for the simultaneous determination of lumefantrine, artemether, and its active metabolite dihydroartemisinin in rat plasma was developed and validated. The chromatographic separation was performed on an ACQUITY UPC2™ BEH 2‐EP column within 2.5 min by gradient elution using compressed CO2 and methanol containing 2 mM ammonium acetate...

Read More thumbnail image: A sensitive highthroughput and ecofriendly method for the determination of lumefantrine artemether and its active metabolite dihydroartemisinin by supercritical fluid chromatography and tandem mass spectrometry

Continuous wave electron paramagnetic resonance of nitroxide biradicals in fluid solution

Published: May 25, 2018

Author(s): Sandra S. Eaton, Lukas B. Woodcock, Gareth R. Eaton

Journal: Concepts in Magnetic Resonance Part A

Abstract Nitroxide biradicals have been prepared with electron‐electron spin‐spin exchange interaction, J, ranging from weak to very strong. EPR spectra of these biradicals in fluid solution depend on the ratio of J to the nitrogen hyperfine coupling, AN, and the rates of interconversion between conformations with different values of J. For relatively rigid biradicals EPR spectra can be simulated as the superposition of AB splitting patterns arising from different...

Read More thumbnail image: Continuous wave electron paramagnetic resonance of nitroxide biradicals in fluid solution

Analysis of retinol, α ‐tocopherol, 25‐hydroxyvitamin D2 and 25‐hydroxyvitamin D3 in plasma of patients with cardiovascular disease by HPLC–MS/MS method

Published: May 24, 2018

Author(s): Marta Karaźniewicz‐Łada, Anna Główka, Anna Komosa, Łukasz Kruszyna, Agnieszka Graczyk‐Szuster, Maciej Lesiak, Dagmara Sowińska, Juliusz Przysławski

Journal: Biomedical Chromatography

Abstract Fat‐soluble vitamins play a pivotal role in the progression of atherosclerosis and the development of cardiovascular disease. Therefore, plasma monitoring of their concentrations may be useful in the diagnosis of these disorders as well as in the process of treatment. The study aimed to develop and validate an HPLC–MS/MS method for determination of retinol, α‐tocopherol, 25‐hydroxyvitamin D2 and 25‐hydroxyvitamin D3 in plasma of...

Read More thumbnail image: Analysis of retinol  tocopherol 25hydroxyvitamin D2 and 25hydroxyvitamin D3 in plasma of patients with cardiovascular disease by HPLCMSMS method

Inhibitory effects of Danhong Injection and its major constituents on human cytochrome P450 enzymes in vitro

Published: May 24, 2018

Author(s): Lin‐Hu Ye, Xin‐Qian Zhao, Ling‐Ti Kong, Li‐Sha Wang, Xue Tao, Hui Wu, Mei He, Qi Chang

Journal: Biomedical Chromatography

Abstract Danhong Injection (DHI) as a Chinese patent medicine is mainly used to treat ischemic encephalopathy and coronary heart disease in combination with other chemotherapy. However, the information on DHI's potential drug interactions is limited. The goal of this work was to examine the potential P450‐mediated metabolism drug interaction arising from DHI and its active components. The results showed that DHI inhibited CYP2C19,...

Read More thumbnail image: Inhibitory effects of Danhong Injection and its major constituents on human cytochrome P450 enzymes in vitro

NMR in Biomedicine 30th Anniversary Volume Message from the Editor‐in‐Chief

Published: May 24, 2018

Author(s): John Griffiths

Journal: NMR in Biomedicine

Read More thumbnail image: NMR in Biomedicine 30th Anniversary Volume Message from the EditorinChief

Multivariate optimization and characterization of simultaneous removal of binary mixture of Cu(II) and Pb(II) using Fe 3 O 4 @MoS 2 nanoparticles

Published: May 24, 2018

Author(s): Javad Zolgharnein, Mahdieh Rastgordani

Journal: Journal of Chemometrics

Abstract In this study, a facile hydrothermal method was used for the synthesis of Fe3O4@MoS2 magnetic nanoparticles. Then, this compound was used as an efficient adsorbent for the simultaneous removal of Cu(II) and Pb(II) ions from water. The prepared nanoparticles were characterized by scanning electron microscopy, X‐ray diffraction, vibrating sample magnetometer, and Fourier transform infrared spectroscopy. In addition, the effect of...

Read More thumbnail image: Multivariate optimization and characterization of simultaneous removal of binary mixture of CuII and PbII using Fe 3 O 4 MoS 2 nanoparticles

Pressure‐assisted capillary electrophoresis frontal analysis for faster binding constant determination

Published: May 24, 2018

Author(s): Cheng Qian, Su Wang, Hengqing Fu, Robin F. B. Turner, Huihui Li, David D. Y. Chen

Journal: ELECTROPHORESIS

Abstract Adding external pressure during the process of capillary electrophoresis usually add to the band broadening, especially if the pressure induced flow is significant. The resolution is normally negatively affected in pressure‐assisted capillary electrophoresis (PACE). Frontal analysis (FA), however, can potentially benefit from using an external pressure while avoiding the drawbacks in other modes of CE. In this work,...

Read More thumbnail image: Pressureassisted capillary electrophoresis frontal analysis for faster binding constant determination

A microfluidic glucose sensor incorporating a novel thread‐based electrode system

Published: May 24, 2018

Author(s): Michelle Gaines, Maria Jose Gonzalez‐Guerrero, Kathryn Uchida, Frank A. Gomez

Journal: ELECTROPHORESIS

Abstract An electrochemical sensor for the detection of glucose using thread‐based electrodes and fabric is described. This device is relatively simple to fabricate and can be used for multiple readings after washing with ethanol. The fabrication of the chip consisted of two steps. First, three thread‐based electrodes (reference, working, and counter) were fabricated by painting pieces of nylon thread with either layered silver ink...

Read More thumbnail image: A microfluidic glucose sensor incorporating a novel threadbased electrode system

Concurrent determination and separation of inorganic cations and anions in microchip electrophoresis with precisely controlled high‐voltage

Published: May 24, 2018

Author(s): Zhe Huang, Mingpeng Yang, Hui You, Yang Xie

Journal: ELECTROPHORESIS

Abstract An improved method for the concurrent determination and separation of cations and anions by microchip electrophoresis with capacitively coupled contactless conductivity detection (ME‐C4D) is described. Two kinds of microchip structures were designed. The first microchip has a long bent separation channel. And for the defects of the first microchip, the second microchip with a Y‐type separation channel has been proposed. The background ...

Read More thumbnail image: Concurrent determination and separation of inorganic cations and anions in microchip electrophoresis with precisely controlled highvoltage

Omics approaches for food authentication

Published: May 24, 2018

Author(s): Marina Creydt, Markus Fischer

Journal: ELECTROPHORESIS

Abstract The development of analytical strategies to fight against food fraud is currently one of the most developing fields in food science as the food value chain becomes increasingly complex and global. Food can be certified by clear labeling but also by objective analytical methods. As shown recently by several groups, the omics technologies such as genomics, proteomics, metabolomics, and isotopolomics are suitable to prove the...

Read More thumbnail image: Omics approaches for food authentication

Fabrication of thioflavin‐ T ‐modified nanopillared SERS substrates for ultrasensitive beta‐amyloid peptide detection

Published: May 24, 2018

Author(s): Sevde Altuntas, Fatih Buyukserin

Journal: Journal of Raman Spectroscopy

Abstract Alzheimer disease (AD) is a major cause of death in the world, and despite intense efforts, there is still no cure for this neurodegenerative disorder. Therefore, early diagnosis of AD is of prime importance, and extensive studies are being conducted to improve the current early detection capabilities and to identify new potential biomarkers for this disease. Here in, we report the fabrication of a novel nanobiosensor...

Read More thumbnail image: Fabrication of thioflavin T modified nanopillared SERS substrates for ultrasensitive betaamyloid peptide detection

SILAR grown Ag nanoparticles as an efficient large area SERS substrate

Published: May 24, 2018

Author(s): Imran M. Shaikh, Shrikrishna D. Sartale

Journal: Journal of Raman Spectroscopy

Abstract Ag nanoparticles having different size and coverage are grown on large area glass substrate (~10 cm2) using low cost successive ionic layer adsorption and reduction (SILAR) method. The SILAR parameters, such as reduction time and growth cycles are optimized to grow Ag nanoparticles with appropriate size and coverage showing maximum surface enhanced Raman scattering (SERS) enhancement of Rhodamine 6 G(R6G). For fixed growth...

Read More thumbnail image: SILAR grown Ag nanoparticles as an efficient large area SERS substrate

Phase I metabolism of the carbazole‐derived synthetic cannabinoids EG‐018, EG‐2201, and MDMB‐CHMCZCA and detection in human urine samples

Published: May 23, 2018

Author(s): Lukas Mogler, Florian Franz, Maurice Wilde, Laura M. Huppertz, Sebastian Halter, Verena Angerer, Bjoern Moosmann, Volker Auwärter

Journal: Drug Testing and Analysis

Abstract Synthetic cannabinoids (SCs) are a structurally diverse class of new psychoactive substances. Most SCs used for recreational purposes are based on indole or indazole core structures. EG‐018 (naphthalen‐1‐yl(9‐pentyl‐9H‐carbazol‐3‐yl)methanone), EG‐2201 ((9‐(5‐fluoropentyl)‐9H‐carbazol‐3‐yl)(naphthalen‐1‐yl)methanone), and MDMB‐CHMCZCA (methyl 2‐(9‐(cyclohexylmethyl)‐9H‐carbazole‐3‐carboxamido)‐3,3‐dimethylbutanoate) are 3 representatives of a...

Read More thumbnail image: Phase I metabolism of the carbazolederived synthetic cannabinoids EG018 EG2201 and MDMBCHMCZCA and detection in human urine samples

Synthesis, analytical characterization, and monoamine transporter activity of the new psychoactive substance 4‐methylphenmetrazine (4‐MPM), with differentiation from its ortho ‐ and meta ‐ positional isomers

Published: May 23, 2018

Author(s): Gavin McLaughlin, Michael H. Baumann, Pierce V. Kavanagh, Noreen Morris, John D. Power, Geraldine Dowling, Brendan Twamley, John O'Brien, Gary Hessman, Folker Westphal, Donna Walther, Simon D. Brandt

Journal: Drug Testing and Analysis

Abstract The availability of new psychoactive substances (NPS) on the recreational drug market continues to create challenges for scientists in the forensic, clinical and toxicology fields. Phenmetrazine (3‐methyl‐2‐phenylmorpholine) and an array of its analogs form a class of psychostimulants that are well documented in the patent and scientific literature. The present study reports on two phenmetrazine analogs that have been...

Read More thumbnail image: Synthesis analytical characterization and monoamine transporter activity of the new psychoactive substance 4methylphenmetrazine 4MPM with differentiation from its ortho  and meta  positional isomers

Infrared and Raman spectroscopy of α‐ZrW 2 O 8 : A comprehensive density functional perturbation theory and experimental study

Published: May 23, 2018

Author(s): Philippe F. Weck, Margaret E. Gordon, Jeffery A. Greathouse, Charles R. Bryan, Stephen P. Meserole, Mark A. Rodriguez, Clay Payne, Eunja Kim

Journal: Journal of Raman Spectroscopy

Abstract Cubic zirconium tungstate (α‐ZrW2O8), a well‐known negative thermal expansion material, has been investigated within the framework of density functional perturbation theory (DFPT), combined with experimental characterization to assess and validate computational results. Using combined Fourier transform infrared measurements and DFPT calculations, new and extensive assignments were made for the far‐infrared (<400 cm−1) spectrum...

Read More thumbnail image: Infrared and Raman spectroscopy of ZrW 2 O 8  A comprehensive density functional perturbation theory and experimental study

Preparative enantioseparation of loxoprofen precursor by recycling countercurrent chromatography with hydroxypropyl‐β‐cyclodextrin as a chiral selector

Published: May 22, 2018

Author(s): Hui Zhang, Xujun Qiu, Liqiong Lv, Wenyu Sun, Chaoyue Wang, Jizhong Yan, Shengqiang Tong

Journal: Journal of Separation Science

Abstract Recycling countercurrent chromatography was successfully applied to the resolution of 2‐(4‐bromomethylphenyl)propionic acid, a key synthetic intermediate for synthesis of nonsteroidal anti‐inflammatory drug loxoprofen, using hydroxypropyl‐β‐cyclodextrin as chiral selector. The two‐phase solvent system composed of n‐hexane/n‐butyl acetate/0.1 mol/L citrate buffer solution with pH 2.4 (8:2:10, v/v/v) was selected....

Read More thumbnail image: Preparative enantioseparation of loxoprofen precursor by recycling countercurrent chromatography with hydroxypropylcyclodextrin as a chiral selector

Multi‐similarity measurement driven ensemble just‐in‐time learning for soft sensing of industrial processes

Published: May 22, 2018

Author(s): Xiaofeng Yuan, Jiao Zhou, Yalin Wang, Chunhua Yang

Journal: Journal of Chemometrics

Abstract Just‐in‐time learning (JITL) technique has been widely used for adaptive soft sensing of nonlinear processes. It builds online local model with the most relevant samples from historical dataset whenever a query sample comes. Hence, the prediction performance greatly depends on the similarity measurement for relevant sample selection. Different similarity measurements have been developed for sample selection in the past...

Read More thumbnail image: Multisimilarity measurement driven ensemble justintime learning for soft sensing of industrial processes
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