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A continuous flow microfluidic device based on contactless dielectrophoresis for bioparticles enrichment

Published: Sep 25, 2017

Author(s): Ali Rahmani, Aliasghar Mohammadi, Hamid Reza Kalhor

Journal: ELECTROPHORESIS

Abstract In recent years, applications of dielectrophoresis‐based platforms have been recognized as effective and dependable approach to separate cells and bioparticles, suspended in different carrier fluids, based on particle size and electrical properties. In this study, a microfluidic device was fabricated by an unprecedented electrode pattern, and several experiments were performed to enrich samples including either of yeast,...

Read More thumbnail image: A continuous flow microfluidic device based on contactless dielectrophoresis for bioparticles enrichment

Recent advances in metal‐organic frameworks and covalent organic frameworks for sample preparation and chromatographic analysis

Published: Sep 25, 2017

Author(s): Xuan Wang, Nengsheng Ye

Journal: ELECTROPHORESIS

Abstract In the field of analytical chemistry, sample preparation and chromatographic separation are two core procedures. The means by which to improve the sensitivity, selectivity and detection limit of a method have become a topic of great interest. Recently, porous organic frameworks, such as metal‐organic frameworks (MOFs) and covalent organic frameworks (COFs), have been widely used in this research area because of their...

Read More thumbnail image: Recent advances in metalorganic frameworks and covalent organic frameworks for sample preparation and chromatographic analysis

Pencil graphite electrodes for improved electrochemical detection of oleuropein by the combination of Natural Deep Eutectic Solvents and graphene oxide

Published: Sep 25, 2017

Author(s): Federico J. V. Gomez#, Adrian Spisso, María Fernanda Silva

Journal: ELECTROPHORESIS

Abstract A novel methodology is presented for the enhanced electrochemical detection of oleuropein in complex plant matrices by Graphene Oxide Pencil Grahite Electrode (GOPGE) in combination with a buffer modified with a Natural Deep Eutectic Solvent, containing 10% (v/v) of Lactic acid, Glucose and H2O (LGH). The electrochemical behavior of oleuropein in the modified‐working buffer was examined using differential pulse voltammetry. ...

Read More thumbnail image: Pencil graphite electrodes for improved electrochemical detection of oleuropein by the combination of Natural Deep Eutectic Solvents and graphene oxide

Investigation of pharmacokinetics, tissue distribution and excretion of schisandrin B in rats by HPLC–MS/MS

Published: Sep 24, 2017

Author(s): Zhuo Wang, Linjun You, Yan Cheng, Kaiyong Hu, Zhanbo Wang, Yanan Cheng, Jin Yang, Yong Yang, Guangji Wang

Journal: Biomedical Chromatography

Abstract Schisandrin B has received much attention owing to its various biological activities. The present study was aimed at the formulation development of schisandrin B and investigation of the pharmacokinetic profiles, distribution and excretion of schisandrin B in Sprague–Dawley rats. In this study, micronized schisandrin B particles with particle size of 10–20 μm were chosen as the research object. Chromatographic separation...

Read More thumbnail image: Investigation of pharmacokinetics tissue distribution and excretion of schisandrin B in rats by HPLCMSMS

Utilization of nondestructive techniques for analysis of the Martian meteorite NWA 6963 and its implications for astrobiology

Published: Sep 24, 2017

Author(s): Bruno L. Nascimento‐Dias, Davi F. Oliveira, Alessandra S. Machado, Olga M.O. Araújo, Ricardo T. Lopes, Marcelino J. Anjos

Journal: X-Ray Spectrometry

Martian meteorites are excellent study materials for understanding the present and past of Mars, as they are important historical astrophysical artifacts because they possess information about Martian geological evolution and physical and chemical characteristics. In our case, we analyzed the NWA 6963 Martian meteorite classified as basaltic shergottite because of its chemical structure. A computerized microtomography (μCT) study in the...

Read More thumbnail image: Utilization of nondestructive techniques for analysis of the Martian meteorite NWA 6963 and its implications for astrobiology

Study of organic acids in Schisandrae Chinensis Fructus after vinegar processing

Published: Sep 22, 2017

Author(s): Fangzhou Yin, Hui Dai, Lin Li, Tuling Lu, Weidong Li, Baochang Cai, Wu Yin

Journal: Journal of Separation Science

Abstract The ripened fruit of Schisandrae Chinensis Fructus has unique medical properties in Chinese medicine. It is commonly used after vinegar steaming. Vinegar steaming changes the color of Schisandrae Chinensis Fructus from red to black and enhances its acidic and astringent properties. Lignans are the well‐investigated components in this herb. However, Schisandrae Chinensis Fructus is acidic in the theory of Chinese medicine,...

Read More thumbnail image: Study of organic acids in Schisandrae Chinensis Fructus after vinegar processing

Polypyrrole‐magnetite dispersive micro‐solid‐phase extraction combined with ultraviolet‐visible spectrophotometry for the determination of rhodamine 6G and crystal violet in textile wastewater

Published: Sep 22, 2017

Author(s): Amirah Farhan Kamaruddin, Mohd Marsin Sanagi, Wan Aini Wan Ibrahim, Dyia S. Md. Shukri, Aemi S. Abdul Keyon

Journal: Journal of Separation Science

Abstract Polypyrrole‐magnetite dispersive micro‐solid‐phase extraction method combined with ultraviolet‐visible spectrophotometry was developed for the determination of selected cationic dyes in textile wastewater. Polypyrrole‐magnetite was used as adsorbent due to its thermal stability, magnetic properties, and ability to adsorb Rhodamine 6G and crystal violet. Dispersive micro‐solid‐phase extraction parameters were optimized,...

Read More thumbnail image: Polypyrrolemagnetite dispersive microsolidphase extraction combined with ultravioletvisible spectrophotometry for the determination of rhodamine 6G and crystal violet in textile wastewater

Magnetic dispersive solid‐phase extraction based on modified magnetic nanoparticles for the detection of cocaine and cocaine metabolites in human urine by high‐performance liquid chromatography–mass spectrometry

Published: Sep 22, 2017

Author(s): Feiyu Yang, Yun Zou, Chunfang Ni, Rong Wang, Min Wu, Chen Liang, Jiabin Zhang, Xiaoliang Yuan, Wenbin Liu

Journal: Journal of Separation Science

Abstract An easy‐to‐handle magnetic dispersive solid‐phase extraction procedure was developed for preconcentration and extraction of cocaine and cocaine metabolites in human urine. Divinyl benzene and vinyl pyrrolidone functionalized silanized Fe3O4 nanoparticles were synthesized and used as adsorbents in this procedure. Scanning electron microscopy, vibrating sample magnetometry, and infrared spectroscopy were employed to characterize the...

Read More thumbnail image: Magnetic dispersive solidphase extraction based on modified magnetic nanoparticles for the detection of cocaine and cocaine metabolites in human urine by highperformance liquid chromatographymass spectrometry

Orthogonal strategy development using reversed macroporous resin coupled with hydrophilic interaction liquid chromatography for the separation of ginsenosides from ginseng root extract

Published: Sep 22, 2017

Author(s): Yajun Wu, Jingjing Liu, Su Gu, Li Lin, Yingzhuang Chen, Ming Ma, Bo Chen

Journal: Journal of Separation Science

Abstract Ginsenosides have been widely conceded as having various biological activities and are considered to be the active ingredient of ginseng. Nowadays, preparative high‐performance liquid chromatography is considered to be a highly efficient method for ginseng saponins purification and preparation. However, in the process of practical application, due to the complex and varied composition of natural products and relatively...

Read More thumbnail image: Orthogonal strategy development using reversed macroporous resin coupled with hydrophilic interaction liquid chromatography for the separation of ginsenosides from ginseng root extract

Simple and sensitive determination of malondialdehyde in human urine and saliva using UHPLC–MS/MS after derivatization with 3,4‐diaminobenzophenone

Published: Sep 22, 2017

Author(s): Jin‐Aa Oh, Ho‐Sang Shin

Journal: Journal of Separation Science

Abstract Malondialdehyde has been used as a biomarker for lipid peroxidation in biological samples. An ultra‐high performance liquid chromatography with tandem mass spectrometry method was developed to determine the levels of malondialdehyde in human urine and saliva samples. To select the optimum derivatization reagent from four diamino compounds, the reactivity and sensitivity of their derivatives were compared, and...

Read More thumbnail image: Simple and sensitive determination of malondialdehyde in human urine and saliva using UHPLCMSMS after derivatization with 34diaminobenzophenone

Simultaneous detection of glutathione and lactate using spectral editing at 3 T

Published: Sep 22, 2017

Author(s): Kimberly L. Chan, Karim Snoussi, Richard A.E. Edden, Peter B. Barker

Journal: NMR in Biomedicine

Two spectral editing techniques for the simultaneous detection of glutathione (GSH) and lactate (Lac) in the human brain at 3 T are described and evaluated. These methods, ‘sMEGA’ (sinc‐MEscher and GArwood) and ‘DEW’ (Double Editing With), were optimized to detect GSH and Lac simultaneously at 3 T using density‐matrix simulations and validation in phantoms. Simulations to test for co‐edited metabolites within the detected GSH...

Read More thumbnail image: Simultaneous detection of glutathione and lactate using spectral editing at 3T

Size‐resolved analysis of fine and ultrafine fractions of indoor particulate matter using energy dispersive X‐ray fluorescence and electron microscopy

Published: Sep 21, 2017

Author(s): Nasser M. Hamdan, Hussain Alawadhi, Najeh Jisrawi, Mohamad Shameer

Journal: X-Ray Spectrometry

We used a multistage PIXE inertial impactor with nine different aerodynamic diameter ranges (between 16 and 0.06 μm) to sample indoor particulate matter (PM). X‐ray fluorescence (XRF) measurements performed at cutoff diameters (CoDs) of 0.25, 0.5, 1, 2, 4, and 8 μm were used to identify elements in various size fractions. Anthropogenic sources were the dominant sources for fine and ultrafine particle sizes. The XRF results show...

Read More thumbnail image: Sizeresolved analysis of fine and ultrafine fractions of indoor particulate matter using energy dispersive Xray fluorescence and electron microscopy

Determination of betaine, l ‐carnitine, and choline in human urine using a self‐packed column and column‐switching ion chromatography with nonsuppressed conductivity detection

Published: Sep 21, 2017

Author(s): Dan Wei, Junwei Liu, Ming Guo, Yan Zhu

Journal: Journal of Separation Science

Abstract A simple method for the determination of betaine, l‐carnitine, and choline in human urine was developed based on column‐switching ion chromatography coupled with nonsuppressed conductivity detection by using a self‐packed column. A pretreatment column (50 mm × 4.6 mm, id) packed with poly(glycidyl methacrylate‐divinylbenzene) microspheres was used for the extraction and cleanup of analytes. Chromatographic separation ...

Read More thumbnail image: Determination of betaine l carnitine and choline in human urine using a selfpacked column and columnswitching ion chromatography with nonsuppressed conductivity detection

Monitoring quality consistency of Liuwei Dihuang Pill by integrating the ultraviolet spectroscopic fingerprint, a multi‐wavelength fusion fingerprint method, and antioxidant activities

Published: Sep 21, 2017

Author(s): Bo Yan, Guoxiang Sun

Journal: Journal of Separation Science

Abstract Liuwei Dihuang Pill, a classical traditional Chinese medicine, has been widely used to treat kidney yin deficiency in China for hundreds of years. Little attention, however, has been paid to quality control methods for this formulation. In the present study, we aimed to establish a comprehensive and practical quality evaluation system for Liuwei Dihuang Pill. Thus, ultraviolet spectroscopic fingerprints and multi‐wavelength...

Read More thumbnail image: Monitoring quality consistency of Liuwei Dihuang Pill by integrating the ultraviolet spectroscopic fingerprint a multiwavelength fusion fingerprint method and antioxidant activities

Quantitative analysis of clofazimine (Lamprene®), an antileprosy agent, in human dried blood spots using liquid chromatography–tandem mass spectrometry

Published: Sep 20, 2017

Author(s): Wenkui Li, John Doherty, Yunlin Fu, Jimmy Flarakos

Journal: Biomedical Chromatography

Abstract An LC–MS/MS method was developed and validated for bioanalysis of clofazimine in human dried blood spot (DBS) samples in support of a clinical study on multidrug‐resistant tuberculosis in developing countries. The validated assay dynamic range was from 10.0 to 2000 ng/mL using a 1/8 inch DBS punch. The accuracy and precision of the assay were ±11.0% (bias) and ≤13.5% (CV) for the LLOQs (10.0 ng/mL) and ±15% (bias) and ≤15%...

Read More thumbnail image: Quantitative analysis of clofazimine Lamprene an antileprosy agent in human dried blood spots using liquid chromatographytandem mass spectrometry

Recent advances in CE and microchip‐CE in clinical applications: 2014 to mid‐2017

Published: Sep 20, 2017

Author(s): Terry M. Phillips

Journal: ELECTROPHORESIS

Abstract CE and microchip CE (ME) are powerful tools for the analysis of a number of different analytes and have been applied to a variety of clinical fields and human samples. This review will present an overview of the most recent applications of these techniques to different areas of clinical medicine during the period of 2014 to mid‐2017. CE and ME have been applied to clinical chemistry, drug detection and monitoring,...

Read More thumbnail image: Recent advances in CE and microchipCE in clinical applications 2014 to mid2017

A covalent capillary coating of diazoresin and polyglycerol dendrimer for protein analysis using capillary electrophoresis

Published: Sep 20, 2017

Author(s): Bing Yu, Minghong Wang, Hailin Cong, Guoling Li

Journal: ELECTROPHORESIS

Abstract Overcoming proteins adsorption on the inner surface of capillary has attracted increasing attention recently. By using the unique photochemistry reaction of diazoresin (DR), a new covalent capillary coating was prepared on the fused‐silica capillary through layer‐by‐layer self‐assembly of DR with polyglycerol (PG) dendrimer. The separation performance of covalently DR/PG‐dendrimer coated capillary noticeably exceeded the...

Read More thumbnail image: A covalent capillary coating of diazoresin and polyglycerol dendrimer for protein analysis using capillary electrophoresis

Extended specificity studies of mRNA assays used to infer human organ tissues and body fluids

Published: Sep 20, 2017

Author(s): Margreet den Berge, Titia Sijen

Journal: ELECTROPHORESIS

Abstract Messenger RNA (mRNA) profiling is a technique increasingly applied for the forensic identification of body fluids and skin. More recently, an mRNA‐based organ typing assay was developed which allows for the inference of brain, lung, liver, skeletal muscle, heart, kidney, and skin tissue. When applying this organ typing system in forensic casework for the presence of animal, rather than human, tissue is an alternative...

Read More thumbnail image: Extended specificity studies of mRNA assays used to infer human organ tissues and body fluids

Polymethacrylate‐based monoliths as stationary phases for separation of biopolymers and immobilization of enzymes

Published: Sep 20, 2017

Author(s): Tamara Martinović, Djuro Josić

Journal: ELECTROPHORESIS

Abstract The experiences in the production and application of polymethacrylate‐based monolithic supports, since their development almost thirty years ago, are presented. The main driving force for the development of new chromatographic supports was the necessity for the isolation and separation of physiologically active biopolymers and their use for therapeutic purposes. For this sake, a development of a method for fast separation,...

Read More thumbnail image: Polymethacrylatebased monoliths as stationary phases for separation of biopolymers and immobilization of enzymes

An automated data‐driven DSP development approach for glycoproteins from yeast

Published: Sep 20, 2017

Author(s): Vignesh Rajamanickam, Maximillian Krippl, Christoph Herwig, Oliver Spadiut

Journal: ELECTROPHORESIS

Abstract Downstream process development for recombinant glycoproteins from yeast is cumbersome due to hyperglycosylation of target proteins. In a previous study, we purified three recombinant glycoproteins from Pichia pastoris using a simple two‐step flowthrough mode approach using monolithic columns. In this study, we investigated a novel automated data science approach for identifying purification conditions for such glycoproteins using...

Read More thumbnail image: An automated datadriven DSP development approach for glycoproteins from yeast
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