Journal Highlight: Scanning X-ray diffraction on cardiac tissue: automatized data analysis and processing

Skip to Navigation

Ezine

  • Published: Dec 4, 2017
  • Author: spectroscopyNOW
  • Channels: X-ray Spectrometry
thumbnail image: Journal Highlight: Scanning X-ray diffraction on cardiac tissue: automatized data analysis and processing

A scanning X-ray diffraction study of cardiac tissue has been performed covering the entire cross section of a mouse heart slice and could be easily extended to characterize tissue from a diseased heart.

Scanning X-ray diffraction on cardiac tissue: automatized data analysis and processing

Journal of Synchrotron Radiation, 2017, 24, 1163-1172
Jan-David Nicolas, Marten Bernhardt, Andrea Markus, Frauke Alves, Manfred Burghammer and Tim Salditt

Abstract: A scanning X-ray diffraction study of cardiac tissue has been performed, covering the entire cross section of a mouse heart slice. To this end, moderate focusing by compound refractive lenses to micrometer spot size, continuous scanning, data acquisition by a fast single-photon-counting pixel detector, and fully automated analysis scripts have been combined. It was shown that a surprising amount of structural data can be harvested from such a scan, evaluating the local scattering intensity, interfilament spacing of the muscle tissue, the filament orientation, and the degree of anisotropy. The workflow of data analysis is described and a data analysis toolbox with example data for general use is provided. Since many cardiomyopathies rely on the structural integrity of the sarcomere, the contractile unit of cardiac muscle cells, the present study can be easily extended to characterize tissue from a diseased heart.

  • This paper is free to view for all users registered on spectroscopyNOW.com until the end of February 2018.
    After this time, you can purchase it using Pay-Per-View on Wiley Online Library.

Follow us on Twitter!

Social Links

Share This Links

Bookmark and Share

Microsites

Suppliers Selection
Societies Selection

Banner Ad

Click here to see
all job opportunities

Copyright Information

Interested in separation science? Visit our sister site separationsNOW.com

Copyright © 2017 John Wiley & Sons, Inc. All Rights Reserved