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Ocean acidification: Sea urchin proteome response

Date: Jun 6, 2019

Author: Steve Down

Close examination of the immune cells of sea urchins living near carbon dioxide vents in their natural aquatic environment suggests that they will be able to adapt to life in the oceans as acidification increases due to anthropogenic impact.

Read More thumbnail image: Ocean acidification Sea urchin proteome response

Journal Highlight: Transcriptome and proteome analysis of steady‐state in a perfusion CHO cell culture process

Date: May 20, 2019

Author: spectroscopyNOW

The impact of perfusion cultivation on the intracellular physiological state of a CHO cell line producing a monoclonal antibody has been studied by global transcriptomics and proteomics.

Read More thumbnail image: Journal Highlight Transcriptome and proteome analysis of steadystate in a perfusion CHO cell culture process

Honey proteome: Novel allergens and venom-like proteins

Date: May 17, 2019

Author: Steve Down

The protein compositions of 13 different types of honey have been determined by mass spectrometry, revealing strong similarities and several novel proteins which could be associated with the food's curative properties.

Read More thumbnail image: Honey proteome Novel allergens and venom-like proteins

Hand, foot and mouth disease: Serum protein biomarkers

Date: May 2, 2019

Author: Steve Down

Two strong protein candidates for biomarkers of the childhood condition hand, foot and mouth disease have been identified in a proteomics study, opening the gates to earlier diagnosis and more timely treatment.

Read More thumbnail image: Hand foot and mouth disease Serum protein biomarkers

Journal Highlight: Advances of proteomics in novel PTM discovery: Applications in cancer therapy

Date: Apr 23, 2019

Author: spectroscopyNOW

This review discusses methods for global post-translational modification identification in proteins which have been linked with the progression of cancer, including antibody‐based enrichment and chemical probe‐based identification.

Read More thumbnail image: Journal Highlight Advances of proteomics in novel PTM discovery Applications in cancer therapy

Hair loss laser treatment: Protein changes point to mechanism

Date: Apr 17, 2019

Author: Steve Down

A proteomic study of the hair follicles of men following low-level laser therapy to reverse the common form of hair loss known as androgenetic alopecia has highlighted the proteins involved and supported the use of this form of treatment.

Read More thumbnail image: Hair loss laser treatment Protein changes point to mechanism

Liver cancer biomarkers: SELDI MS tissue discovery

Date: Apr 4, 2019

Author: Steve Down

Several proteins that distinguish hepatocellular carcinoma from neighbouring healthy tissue have been identified by SELDI-TOF MS and their association with disease-free survival has been assessed.

Read More thumbnail image: Liver cancer biomarkers SELDI MS tissue discovery

Journal Highlight: Targeted proteomics comes to the benchside and the bedside: Is it ready for us?

Date: Mar 26, 2019

Author: spectroscopyNOW

An overview of the knowledge required to perform targeted proteomics and its applications is provided, in the context of provision at the benchside for basic research and at the bedside for the good of patients.

Read More thumbnail image: Journal Highlight Targeted proteomics comes to the benchside and the bedside Is it ready for us

Metal nanoparticle biocoronas: Protein binding in serum

Date: Mar 20, 2019

Author: Steve Down

The identities of 200 proteins that form biocoronas around three types of metallic nanoparticles upon immersion in human serum have been determined, to assess the implications for immune safety, toxicology, and the design of novel biosensors.

Read More thumbnail image: Metal nanoparticle biocoronas Protein binding in serum

Novel top-down protein platform: Serial SEC with FTICR mass spectrometry

Date: Mar 6, 2019

Author: Steve Down

Mixtures of intact proteins with closely related molecular masses that were extracted from heart tissue have been resolved and identified by high-resolution FT/ICR mass spectrometry following serial size exclusion chromatography.

Read More thumbnail image: Novel top-down protein platform Serial SEC with FTICR mass spectrometry
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