Green silver nanoparticles: UV characterisation

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  • Published: Aug 1, 2019
  • Author: David Bradley
  • Channels: UV/Vis Spectroscopy
thumbnail image: Green silver nanoparticles: UV characterisation

Biosynthesised nano

Green synthesis of silver nanoparticles from Alpinia officinarum mitigates cisplatin-induced nephrotoxicity via down-regulating apoptotic pathway in rats

Silver nanoparticles can be synthesised in a relatively environmentally benign manner using the plant lesser galangal, Alpinia officinarum, a member of the ginger family. The resulting particles were characterised by UV-Vis spectroscopy, Fourier-transform Infrared (FTIR) spectroscopy, X-ray diffraction, transmission electron microscopy (TEM), and Selected area electron diffraction (SAED) and shown to carry with them active chemical components from the plant. They have been shown to have potential in mitigating the kidney damage caused by cancer therapy that uses the drug cis-platin.

The rhizome of A. officinarum is known to have pharmacological properties. It contains antioxidants, anti-inflammatory, antiapoptotic compounds, and has also been shown to have anticancer activity. Of course, its use in its native form as some kind of herbal remedy is of limited utility in modern medicine not least because of poor bioavailability and putative toxic effects of congeners present in any "herbal" preparation, such as other metabolites and contaminants from the plant's growing environment.

Improving cancer chemotherapy

In order to work around this issue, an international team has turned to nanotechnology to create a novel class of drug. Zhiping Zhang, Guangda Xin, Guangyu Zhou, Qianyu Li, Feng Liu, and Dayu Wang of China-Japan Union Hospital of Jilin University in Changchun, Jilin, China and colleagues Vishnu Priya Veeraraghavan of Saveetha University in Chennai, India, and Surapaneni Krishna Mohan of the Imam Abdulrahman Bin Faisal University in Al Jubail, Kingdom of Saudi Arabia outline details in the journal Artificial Cells, Nanomedicine, and Biotechnology.

The researchers have successfully tested the modified silver nanoparticles in a laboratory rat model. They assessed the antioxidant and the kidney protective, or nephroprotective, properties of the biosynthesized nanoparticles by looking at levels of kidney biomarkers, cytokine, inflammatory markers, free radicals and antioxidants present in control and experimental animals. The positive data from these experiments suggests that this new material might be a useful adjunct to cis-platin therapy.

Kidney protection

Cis-platin, cis-diamminedichloroplatinum, has been used for many years in treating a range of cancers including testicular, ovarian, bladder, lung, cervical, head and neck cancers. Indeed, for many patients it is the only chemotherapy option and it is very successful in a large number of cases. Unfortunately, as with all medication it has side effects, one of the most significant being kidney damage. The team's new biosynthesised nanoparticles might ultimately be used to ameliorate this effect. The researchers suggest that the new compound works to scavenge free radicals generated by the cis-platin and so protect the renal tissue from harm.

Related Links

Artif Cells Nanomed Biotechnol 2019, online: "Green synthesis of silver nanoparticles from Alpinia officinarum mitigates cisplatin-induced nephrotoxicity via down-regulating apoptotic pathway in rats"

Article by David Bradley

The views represented in this article are solely those of the author and do not necessarily represent those of John Wiley and Sons, Ltd.

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