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Liquid chromatographic methods for separation, determination, and bioassay of enantiomers of etodolac: A review

Published: Aug 23, 2019

Author(s): Manisha Singh, Sonika Sethi, Ravi Bhushan

Journal: Journal of Separation Science

Abstract The control of enantiomeric purity and determination of individual enantiomeric drug molecules remains the subject of importance for clinical, analytical, and regulatory purposes and to facilitate an accurate evaluation of the risks posed by them to human health. A large number of pharmaceuticals are marketed and administered as racemates. Etodolac is among such nonsteroidal anti‐inflammatory drugs. Overall literature reports on its enantioseparation are scanty. Liquid chromatography...

Read More thumbnail image: Liquid chromatographic methods for separation determination and bioassay of enantiomers of etodolac A review

The experimental design approach to the optimization of a simple quick easy cheap effective rugged and safe method for the analysis of phytoestrogens in complex soy‐based food

Published: Aug 23, 2019

Author(s): Barbara Benedetti, Emanuele Magi, Marina Di Carro

Journal: Journal of Separation Science

Abstract The present paper deals with the multivariate optimization of an extraction‐purification strategy for the determination of phytoestrogens (daidzein, genistein, coumestrol, formononetin, and biochanin A) in soy‐based meat substitutes by high performance liquid chromatography with tandem mass spectrometry. For a reliable quantitation of these new concerning compounds in such a complex matrix, recovery and matrix effect must be carefully evaluated. Therefore, two sequential experimental...

Read More thumbnail image: The experimental design approach to the optimization of a simple quick easy cheap effective rugged and safe method for the analysis of phytoestrogens in complex soybased food

Determination of trace hydroxyl polycyclic aromatic hydrocarbons in urine using graphene oxide incorporated monolith solid‐phase extraction coupled with LC‐MS/MS

Published: Aug 23, 2019

Author(s): Zi‐Ling Li, Na Li, Li Du, Ya‐Hui Wang, Bo Fang, Man‐Man Wang, Qian Wang

Journal: Journal of Separation Science

Abstract The biomonitoring of hydroxy polycyclic aromatic hydrocarbons in urine, as a direct way to access multiple exposures to polycyclic aromatic hydrocarbons, has raised great concerns due to their increasing hazardous health effects on humans. Solid‐phase extraction is an effective and useful technique to preconcentrate trace analytes from biological samples. Here, we report a novel solid‐phase extraction method using a graphene oxide incorporated monolithic syringe for the determination...

Read More thumbnail image: Determination of trace hydroxyl polycyclic aromatic hydrocarbons in urine using graphene oxide incorporated monolith solidphase extraction coupled with LCMSMS

Strong rotating flow in stationary droplets in low power budget using wire electrode configuration

Published: Aug 23, 2019

Author(s): Golak Kunti, Anandaroop Bhattacharya, Suman Chakraborty

Journal: ELECTROPHORESIS

Abstract We explore a simple strategy of generating strong rotating flow in a stationary surface‐droplet, using an intricate interplay of local electrical and thermal fields. Wire electrodes are employed to generate on‐spot heating without necessitating any elaborate micro‐fabrication, which causes strong local gradients in electrical properties to induce mobile charges into the droplet. Applying a low voltage (∼10 V), strong rotational velocity of the order of mm/s can be achieved in the...

Read More thumbnail image: Strong rotating flow in stationary droplets in low power budget using wire electrode configuration

Deciphering the Raman spectrum of royal jelly. Fabrication of Ag‐polymer embedded royal jelly nanoparticles manifesting SERS effect

Published: Aug 23, 2019

Author(s): Sofija Lazarevska, Nikola Geskovski, Petre Makreski

Journal: Journal of Raman Spectroscopy

Abstract Royal jelly (RJ) is secretion from the hypopharyngeal glands of worker bees, which serves as food for the queen bee and enabling larvae growth. Having biological properties already proven, RJ has considerable commercial appeal and is used in many sectors (pharmacy, food industries, and cosmetic products) nowadays. However, due to its chemical complexity on one hand and the easy adulteration and sensitivity of the biological molecules present, a limited information of the Raman...

Read More thumbnail image: Deciphering the Raman spectrum of royal jelly_ Fabrication of Agpolymer embedded royal jelly nanoparticles manifesting SERS effect

Preparation of porous aromatic framework modified graphene oxide for pipette‐tip solid‐phase extraction of theophylline in tea

Published: Aug 22, 2019

Author(s): Qilin Deng, Liping Sun, Tao Zhu

Journal: ELECTROPHORESIS

Abstract A new material called as porous aromatic frameworks modified graphene oxide (PAFs‐GO) was synthesized, and it was used as an adsorbent in pipette‐tip SPE for the effective purification and enrichment of theophylline in tea sample by HPLC. The properties of PAFs‐GO were characterized by field emission SEM, FTIR, thermogravimetry analysis and Brunauer Emmett Teller N2 adsorption‐desorption analysis. The results of static adsorption and dynamic adsorption test showed PAFs‐GO had higher...

Read More thumbnail image: Preparation of porous aromatic framework modified graphene oxide for pipettetip solidphase extraction of theophylline in tea

A high performance liquid chromatography method for simultaneous detection of 20 bioactive components in tea extracts

Published: Aug 22, 2019

Author(s): Bo Nian, Lijiao Chen, Chao Yi, Xingyun Shi, Bin Jiang, Wenwen Jiao, Qianting Liu, Caiyou Lv, Yan Ma, Ming Zhao

Journal: ELECTROPHORESIS

Abstract Tea is the second most widely consumed beverage and contains various bioactive compounds. A simple method to analyze these compounds is of great scientific and commercial interest. In this work, a 30 min HPLC method was developed using a simple gradient elution system, and the mobile phases and elution gradients were optimized. This method separated 17 polyphenols and three alkaloid compounds in tea extracts, including catechins, alkaloids, phenolic acids, flavonols, and flavone,...

Read More thumbnail image: A high performance liquid chromatography method for simultaneous detection of 20 bioactive components in tea extracts

Indirect CE‐UV detection for the characterization of organic and inorganic ions of a broad mobility and pKa range in engine coolants

Published: Aug 22, 2019

Author(s): Tobias Rösch, Johann Troffer, Carolin Huhn

Journal: ELECTROPHORESIS

Abstract An alternative CE‐(indirect ultraviolet) method for the analysis of inorganic and organic anions in ethylene glycol‐based engine coolants is presented using a BGE with 4 mM pyromellitic acid and 3.4 mM 1,6‐hexamethylene diamine, pH 3. Baseline separation of six inorganic (e.g. nitrite, nitrate, and sulfate) and five organic anions (e.g. acetic and glycolic acid) was achieved. Quantification of 8 out of 11 specified anions was possible in stressed engine coolant samples after simple...

Read More thumbnail image: Indirect CEUV detection for the characterization of organic and inorganic ions of a broad mobility and pKa range in engine coolants

Dumortierite and tourmaline from the Barchi‐Kol diamond‐bearing kyanite gneisses (Kokchetav massif): A Raman spectroscopic study and petrological implications

Published: Aug 22, 2019

Author(s): Andrey V. Korsakov, Olga V. Rezvukhina, Dmitriy I. Rezvukhin, Evgeny D. Greshnyakov, Vladimir Ya. Shur

Journal: Journal of Raman Spectroscopy

Abstract Two minerals of boron, dumortierite and tourmaline, have been studied in a diamondiferous kyanite gneiss (Barchi‐Kol area, Kokchetav massif, Northern Kazakhstan) by Raman spectroscopy and electron microprobe (EMP) analysis. Dumortierite and tourmaline (almost pure schorl end‐member) coexist within the sample, with blue/purple dumortierite inclusions hosted by kyanite porphyroblasts and blue tourmaline crystals occurring as inclusions in garnet. Optically, dumortierite appears almost...

Read More thumbnail image: Dumortierite and tourmaline from the BarchiKol diamondbearing kyanite gneisses Kokchetav massif A Raman spectroscopic study and petrological implications

Multivariate curve resolution methods and the design of experiments

Published: Aug 22, 2019

Author(s): Mathias Sawall, Christoph Kubis, Henning Schröder, Denise Meinhardt, Detlef Selent, Robert Franke, Alexander Brächer, Armin Börner, Klaus Neymeyr

Journal: Journal of Chemometrics

Abstract A major problem of multivariate curve resolution methods is the underlying non‐uniqueness of the pure component decompositions. This raises the question how a chemical experiment should be designed so that the solution ambiguity is as small as possible. Changes of the reaction conditions belong to the possible variations whereas for a fixed chemical reaction system, the pure component spectra appear to be unchangeable. The paper investigates and discusses the possibility to design a...

Read More thumbnail image: Multivariate curve resolution methods and the design of experiments

A practical convolutional neural network model for discriminating Raman spectra of human and animal blood

Published: Aug 22, 2019

Author(s): Jialin Dong, Mingjian Hong, Yi Xu, Xiangquan Zheng

Journal: Journal of Chemometrics

A practical convolutional neural network is proposed to discriminate the Raman spectra of human and animal blood. The network combines the preprocessing and discrimination to form a whole processing unit and learns parameters adaptively by training. Two preprocessing layers, namely, denoising and baseline correction layer, are designed to allow only one kernel for each layer to explicitly suppress the noise and subtract varying background of the spectra.

Read More thumbnail image: A practical convolutional neural network model for discriminating Raman spectra of human and animal blood

Hyperpolarized 13C magnetic resonance spectroscopy detects toxin‐induced neuroinflammation in mice

Published: Aug 22, 2019

Author(s): Lydia M. Le Page, Caroline Guglielmetti, Chloé F. Najac, Brice Tiret, Myriam M. Chaumeil

Journal: NMR in Biomedicine

Lipopolysaccharide (LPS) is a commonly used agent for induction of neuroinflammation in preclinical studies. Upon injection, LPS causes activation of microglia and astrocytes, whose metabolism alters to favor glycolysis. Assessing in vivo neuroinflammation and its modulation following therapy remains challenging, and new noninvasive methods allowing for longitudinal monitoring would be highly valuable. Hyperpolarized (HP) 13C magnetic resonance spectroscopy (MRS) is a promising technique for...

Read More thumbnail image: Hyperpolarized 13C magnetic resonance spectroscopy detects toxininduced neuroinflammation in mice

Spectroscopic investigations of the new anhydrous proton‐conducting compound of pyrazole with oxalate acid

Published: Aug 22, 2019

Author(s): Małgorzata Widelicka, Katarzyna Pogorzelec‐Glaser, Radosław Pankiewicz, Andrzej Łapiński

Journal: Journal of Raman Spectroscopy

Abstract Dicarboxylic acid salts are a good group of compounds in which one can study a variety of supramolecular structures as dimers, catemer chains, and rings and are interesting for crystal engineering of proton conductors for applications in solid‐state hydrogen fuel cells. The optical properties of the new proton‐conducting compound of pyrazole with oxalate acid were investigated using Raman and IR spectroscopy taking into account the formal classification of the fundamental modes. To...

Read More thumbnail image: Spectroscopic investigations of the new anhydrous protonconducting compound of pyrazole with oxalate acid

Identification of the major metabolites of (R)‐salbutamol in human urine, plasma and feces using ultra high performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry

Published: Aug 21, 2019

Author(s): Fengying Ye, Shan Liu, Yang Yang, Ting Zhao, Shuang Li, Ting Zhou, Wen Tan

Journal: Journal of Separation Science

Abstract (R)‐Salbutamol is a selective β2‐adrenoreceptor agonist, which produces a short‐acting bronchodilator effect and is widely used for the treatment of respiratory diseases in humans. Drug metabolism and identification of the metabolites play an essential role in the evaluation of the overall efficacy and safety of the drugs in clinical practices. There are few reports on the identification of major metabolites of (R)‐salbutamol in humans, and the number of identified metabolites is very...

Read More thumbnail image: Identification of the major metabolites of Rsalbutamol in human urine plasma and feces using ultra high performance liquid chromatography coupled with quadrupole timeofflight mass spectrometry

Proteome Dataset of Qualea grandiflora Mart. (Vochysiaceae) by LC–MS/MS Label‐Free Identification in Response to Aluminum

Published: Aug 21, 2019

Author(s): Natália Faustino Cury, Renata Cristina Costa Silva, Michelle Fayad, Wagner Fontes, Carlos André Ornelas Ricart, Mariana de Sousa Castro, Conceição Eneida dos Santos Silveira, Marcelo Valle de Sousa, Luiz Alfredo Rodrigues Pereira

Journal: PROTEOMICS

Abstract This dataset brief is about the descriptive proteome of Qualea grandiflora plants by label free mass spectrometry (LC–MS/MS). Q. grandiflora is a plant that accumulates aluminum (Al) in high quantities and requires it for growth and development. Although quite relevant for the understanding of Al effects on plants, the proteome of Q. grandiflora has not been studied yet. Therefore, the current proteome analysis identifies a total of 2010 proteins. Furthermore, the identified Q....

Read More thumbnail image: Proteome Dataset of Qualea grandiflora Mart_ Vochysiaceae by LCMSMS LabelFree Identification in Response to Aluminum

Analysis of four therapeutic monoclonal antibodies by online capillary isoelectric focusing directly coupled to quadrupole time‐of‐flight mass spectrometry

Published: Aug 20, 2019

Author(s): Lingyu Wang, David Da Yong Chen

Journal: ELECTROPHORESIS

Abstract Capillary isoelectric focusing (cIEF) was online coupled to a Q‐TOF MS by a flow‐through microvial interface for the analysis of therapeutic mAb. Intact molecular weights obtained from the mass spectrum deconvolution of separated charge variants provided information on the structural heterogeneity of therapeutic mAbs. A sandwich cIEF–MS configuration composed of anolyte, sample, and catholyte segments sequentially injected into a neutrally coated capillary was used for the charge...

Read More thumbnail image: Analysis of four therapeutic monoclonal antibodies by online capillary isoelectric focusing directly coupled to quadrupole timeofflight mass spectrometry

OGT Controls the Expression and the Glycosylation of E‐cadherin, and Affects Glycosphingolipid Structures in Human Colon Cell Lines

Published: Aug 20, 2019

Author(s): James Biwi, Charlotte Clarisse, Christophe Biot, Radoslaw Pawel Kozak, Katarina Madunic, Marlène Mortuaire, Manfred Wuhrer, Daniel Ian Richard Spencer, Céline Schulz, Yann Guerardel, Tony Lefebvre, Anne‐Sophie Vercoutter‐Edouart

Journal: PROTEOMICS

Abstract Colorectal cancer (CRC) affects both women and men living in societies with a high sedentary lifestyle. Amongst the phenotypic changes exhibited by tumor cells, a wide range of glycosylation has been reported for colon cancer‐derived cell lines and CRC tissues. These aberrant modifications affect different aspects of glycosylation, including an increase in core fucosylation and GlcNAc branching on N‐glycans, alteration of O‐glycans, upregulated sialylation, and O‐GlcNAcylation....

Read More thumbnail image: OGT Controls the Expression and the Glycosylation of Ecadherin and Affects Glycosphingolipid Structures in Human Colon Cell Lines

Rapid analysis and characterization of multiple constituents of corn silk aqueous extract using ultra‐high‐performance liquid chromatography combined with quadrupole time‐of‐flight mass spectrometry

Published: Aug 20, 2019

Author(s): Yumei Wang, Qi Liu, Songjie Fan, Xueting Yang, Linlin Ming, Huimin Wang, Jianhua Liu

Journal: Journal of Separation Science

Abstract Corn silk is a well‐known traditional Chinese medicine that has been widely used for its antidiabetic, antioxidant, antihyperlipidemic, and other effects in China for thousands of years. Numerous studies have revealed that corn silk contains multiple bioactive constituents that are beneficial for human health. However, the constituents of corn silk in vivo remain ambiguous. In this study, high‐throughput ultra‐high‐performance liquid chromatography combined with quadrupole...

Read More thumbnail image: Rapid analysis and characterization of multiple constituents of corn silk aqueous extract using ultrahighperformance liquid chromatography combined with quadrupole timeofflight mass spectrometry

Simultaneous analysis of indaziflam and its metabolites in pitaya using dispersive solid phase extraction coupled with liquid chromatography coupled with tandem mass spectrometry

Published: Aug 20, 2019

Author(s): Dongqiang Zeng, Xiangyang Yu, Shaozhi Ma, Xuesheng Li, Huihua Tan, Mingfeng Hu, Wenwei Tang, Chunhong Ji, Xiaoliang Liu

Journal: Journal of Separation Science

Abstract A simple and efficient multiresidue method using dispersive solid phase extraction and liquid chromatography coupled with tandem mass spectrometry was developed for the targeted analysis of indaziflam and its five metabolites (indaziflam‐diaminotriazine, indaziflam‐carboxylic acid, indaziflam‐triazine indanone, indaziflam‐hydroxyethyl, and indaziflam‐olefin) in pitaya samples (including roots, plants, flowers, peels, pulp, and whole fruit). The analytes were extracted with...

Read More thumbnail image: Simultaneous analysis of indaziflam and its metabolites in pitaya using dispersive solid phase extraction coupled with liquid chromatography coupled with tandem mass spectrometry

Determination of ethanamizuril, a novel triazine coccidiostat, in rat plasma by ultra‐performance liquid chromatography system‐tandem mass spectrometry and its application in a toxicological study

Published: Aug 20, 2019

Author(s): Xiaoyang Wang, Juan Zhao, Shuya Wei, Chunmei Wang, Lifang Zhang, Mi Wang, Yingchun Liu, Chenzhong Fei, Feiqun Xue, Keyu Zhang

Journal: Biomedical Chromatography

Abstract Ethanamizuril is a new triazine compound that has the potential to be a novel anticoccidial drug. Toxicological studies in experimental rats were performed to understand the safety profile of ethanamizuril for drug product development. In this study, a novel, selective and accurate ultra‐performance liquid chromatography tandem mass spectrometry method has been developed for the determination of ethanamizuril concentrations in rat plasma. With 4‐nitro‐o‐cresol as an internal standard,...

Read More thumbnail image: Determination of ethanamizuril a novel triazine coccidiostat in rat plasma by ultraperformance liquid chromatography systemtandem mass spectrometry and its application in a toxicological study
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